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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 1447 | 4q13.1 | ADGRL3 | adhesion G protein-coupled receptor L3 | |
| Mouse | 7 | 1537 | 5 D-E1 | Adgrl3 | adhesion G protein-coupled receptor L3 | |
| Rat | 7 | 1550 | 14p21 | Adgrl3 | adhesion G protein-coupled receptor L3 | |
| Previous and Unofficial Names |
| LPHN3 (latrophilin 3) | CIRL3 (calcium-independent receptor of alpha-latrotoxin 3) | LEC3 (Lectomedin-3) | CL3 (CIRL/latrophilin 3) |
| Database Links |
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| Specialist databases | |
| GPCRdb | lphn3_human (Hs), agrl3_mouse (Mm), agrl3_rat (Rn) |
| Other databases | |
| Alphafold | Q9HAR2 (Hs), Q80TS3 (Mm), Q9Z173 (Rn) |
| Ensembl Gene | ENSG00000150471 (Hs), ENSMUSG00000037605 (Mm), ENSRNOG00000030149 (Rn) |
| Entrez Gene | 23284 (Hs), 319387 (Mm), 170641 (Rn) |
| Human Protein Atlas | ENSG00000150471 (Hs) |
| KEGG Gene | hsa:23284 (Hs), mmu:319387 (Mm), rno:170641 (Rn) |
| Pharos | Q9HAR2 (Hs) |
| RefSeq Nucleotide | NM_015236 (Hs), NM_198702 (Mm), NM_130822 (Rn) |
| RefSeq Protein | NP_056051 (Hs), NP_941991 (Mm), NP_570835 (Rn) |
| UniProtKB | Q9HAR2 (Hs), Q80TS3 (Mm), Q9Z173 (Rn) |
| Wikipedia | ADGRL3 (Hs) |
| Associated Protein Comments | ||
| Extracellular and transmembrane interactors: teneurin-3 [11], FLRT-1, -3 [11], UNC5A [5]. |
| Natural/Endogenous Ligands |
| FLRT3 {Sp: Rat} |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Agonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
| The interaction between ADGRL3 and FLRT3 is important for the in vivo formation and strength of glutamatergic synaptic inputs in dentate girus granule neurons, but not in CA1 pyramidal neurons. | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
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Gq/G11 family G12/G13 family |
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| References: 8 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Xenobiotics Influencing Gene Expression
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| Biologically Significant Variants
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| General Comments |
| ADGRL3 (formerly LPHN3; latrophilin 3) is a receptor that belongs to Family I Adhesion-GPCRs along with ADGRL1 (latrophilin 1), ADGRL2 (latrophilin 2) and ADGRL4 (ELTD1) [2]. Family I Adhesion-GPCRs have orthologs in vertebrate and invertebrate species. |
1. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domené S, Vélez JI, Karkera JD, Balog J et al.. (2010) A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry, 15 (11): 1053-66. [PMID:20157310]
2. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
3. Haitina T, Olsson F, Stephansson O, Alsiö J, Roman E, Ebendal T, Schiöth HB, Fredriksson R. (2008) Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci, 9: 43. [PMID:18445277]
4. Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG. (1999) A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. J Biol Chem, 274 (9): 5491-8. [PMID:10026162]
5. Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, Del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MS et al.. (2016) Super-complexes of adhesion GPCRs and neural guidance receptors. Nat Commun, 7: 11184. [PMID:27091502]
6. Labbe A, Liu A, Atherton J, Gizenko N, Fortier MÈ, Sengupta SM, Ridha J. (2012) Refining psychiatric phenotypes for response to treatment: contribution of LPHN3 in ADHD. Am J Med Genet B Neuropsychiatr Genet, 159B (7): 776-85. [PMID:22851411]
7. Martinez AF, Muenke M, Arcos-Burgos M. (2011) From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet, 156B (1): 1-10. [PMID:21184579]
8. Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA et al.. (2020) G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. Nat Chem Biol, 16 (12): 1343-1350. [PMID:32778842]
9. Matsushita H, Lelianova VG, Ushkaryov YA. (1999) The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. FEBS Lett, 443 (3): 348-52. [PMID:10025961]
10. Naciff JM, Hess KA, Overmann GJ, Torontali SM, Carr GJ, Tiesman JP, Foertsch LM, Richardson BD, Martinez JE, Daston GP. (2005) Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A. Toxicol Sci, 86 (2): 396-416. [PMID:15901920]
11. O'Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates 3rd JR, Ghosh A. (2012) FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron, 73 (5): 903-10. [PMID:22405201]
12. Regard JB, Sato IT, Coughlin SR. (2008) Anatomical profiling of G protein-coupled receptor expression. Cell, 135 (3): 561-71. [PMID:18984166]
13. Ribasés M, Ramos-Quiroga JA, Sánchez-Mora C, Bosch R, Richarte V, Palomar G, Gastaminza X, Bielsa A, Arcos-Burgos M, Muenke M et al.. (2011) Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study. Genes Brain Behav, 10 (2): 149-57. [PMID:21040458]
14. Sugita S, Ichtchenko K, Khvotchev M, Südhof TC. (1998) alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. J Biol Chem, 273 (49): 32715-24. [PMID:9830014]
15. Zhang H, Dong Y, Zhao H, Brooks JD, Hawthorn L, Nowak N, Marshall JR, Gao AC, Ip C. (2005) Microarray Data Mining for Potential Selenium Targets in Chemoprevention of Prostate Cancer. Cancer Genomics Proteomics, 2 (2): 97-114. [PMID:18548127]
