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activin A receptor type 1C

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Target not currently curated in GtoImmuPdb

Target id: 1790

Nomenclature: activin A receptor type 1C

Abbreviated Name: ALK7

Family: Type I receptor serine/threonine kinases

Quaternary Structure: Complexes
Growth/differentiation factor receptors
Activin receptors
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 493 2q24.1 ACVR1C activin A receptor type 1C
Mouse 1 493 2 C1.1 Acvr1c activin A receptor, type IC
Rat 1 493 3q21 Acvr1c activin A receptor type 1C
Previous and Unofficial Names Click here for help
activin A receptor | activin A receptor type IC | activin receptor-like kinase 7 | ACTR-IC | ACVRLK7 | Alk7 | TGF-beta type 1 receptor
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.30
Natural/Endogenous Ligands Click here for help
growth/differentiation factor-11 {Sp: Human}

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SB-431542 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - - 1-2
[1-2]
Inhibitor Comments
ACVR1C (ALK7) activity is inhibited by 99% in the presence of 2.5μM SB-431542 [2]. Alternatively 8.9% inhibition is reported using 0.1μM compound and 54% inhibition at 1μM [1].

References

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1. Li X, Wang L, Long L, Xiao J, Hu Y, Li S. (2009) Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5). Bioorg. Med. Chem. Lett., 19 (16): 4868-72. [PMID:19616940]

2. Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. (2012) Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J. Med. Chem., 55 (22): 9946-57. [PMID:23130626]

How to cite this page

Type I receptor serine/threonine kinases: activin A receptor type 1C. Last modified on 30/03/2016. Accessed on 07/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1790.