RSTK functional heteromers | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Receptor kinases
TKL: Tyrosine kinase-like
Receptor serine/threonine kinase (RSTK) family
RSTK functional heteromers

RSTK functional heteromers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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For the receptors listed on this page, the exact combination of subunits forming the functional heteromeric receptors is unknown.

Receptors

2587

Complexes

Transforming growth factor β receptor C Show summary »« Hide summary

Bone morphogenetic protein receptors C Show summary »« Hide summary

Growth/differentiation factor receptors C Show summary »« Hide summary

Target Id

2587

Nomenclature

Growth/differentiation factor receptors

Subunits

bone morphogenetic protein receptor type IA (Type I)
activin A receptor type 1B (Type I)
transforming growth factor beta receptor 1 (Type I)
bone morphogenetic protein receptor type IB (Type I)
activin A receptor type 1C (Type I)
activin A receptor type 2A (Type II)
activin A receptor type 2B (Type II)
bone morphogenetic protein receptor type 2 (Type II)

Coupling

Smad1, Smad5, Smad8 [1-2]

Endogenous agonists

growth/differentiation factor-7 (GDF7, Q7Z4P5)

growth/differentiation factor-1 (GDF1, P27539)

growth/differentiation factor-10 (GDF10, P55107)

growth/differentiation factor-3 (GDF3, Q9NR23)

growth/differentiation factor-9 (GDF9, O60383)

Activin receptors C Show summary »« Hide summary

Anti-Müllerian hormone receptors C Show summary »« Hide summary

References

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How to cite this family page

Database page citation:

RSTK functional heteromers. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=797.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.