Quaternary Structure: Complexes

Bone morphogenetic protein receptors

Growth/differentiation factor receptors

Activin receptors

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	512	3p22.2	ACVR2B	activin A receptor type 2B
Mouse	1	536	9 F3	Acvr2b	activin receptor IIB
Rat	1	513	8q32	Acvr2b	activin A receptor type 2B

Previous and Unofficial Names

activin receptor IIB | Activine receptor 2b (transmembrane serine kinase) | Acvr2 | activin receptor 2B | ActRIIB | activin A receptor type IIB

Database Links
Alphafold	Q13705 (Hs), P27040 (Mm), P38445 (Rn)
BRENDA	2.7.11.30
ChEMBL Target	CHEMBL5466 (Hs)
Ensembl Gene	ENSG00000114739 (Hs), ENSMUSG00000061393 (Mm), ENSRNOG00000014477 (Rn)
Entrez Gene	93 (Hs), 11481 (Mm), 25366 (Rn)
Human Protein Atlas	ENSG00000114739 (Hs)
KEGG Enzyme	2.7.11.30
KEGG Gene	hsa:93 (Hs), mmu:11481 (Mm), rno:25366 (Rn)
OMIM	602730 (Hs)
Orphanet	ORPHA159918 (Hs)
Pharos	Q13705 (Hs)
RefSeq Nucleotide	NM_001106 (Hs), NM_007397 (Mm), NM_031554 (Rn)
RefSeq Protein	NP_001097 (Hs), NP_031423 (Mm), NP_113742 (Rn)
UniProtKB	Q13705 (Hs), P27040 (Mm), P38445 (Rn)
Wikipedia	ACVR2B (Hs)

Selected 3D Structures
	Description:  Crystal structure of a ternary ligand-receptor complex of BMP-2 with ActR-IIB PDB Id:  2H62 Resolution:  1.85Å Species:  Human References:  3

Enzyme Reaction
EC Number: 2.7.11.30

Natural/Endogenous Ligands
myostatin {Sp: Human}

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference bimagrumab Hs Binding 11.8 pKd 1 ⤷ pKd 11.8 (Kd 1.73x10-12 M) [1] Description: Binding affinity of clone MOR08159

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4
Key to terms and symbols		Click column headers to sort
Target used in screen: ACVR2B
Ligand Sp. Type Action Value Parameter PP-242 Hs Inhibitor Inhibition 8.1 pKd PD-173955 Hs Inhibitor Inhibition 8.0 pKd KW-2449 Hs Inhibitor Inhibition 6.4 pKd dasatinib Hs Inhibitor Inhibition 6.2 pKd AST-487 Hs Inhibitor Inhibition 5.8 pKd pazopanib Hs Inhibitor Inhibition 5.6 pKd alvocidib Hs Inhibitor Inhibition 5.6 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

Clinically-Relevant Mutations and Pathophysiology
Disease:  Heterotaxy, visceral, 4, autosomal; HTX4 Synonyms: Situs ambiguus [Orphanet: ORPHA157769] Visceral heterotaxy [Disease Ontology: DOID:0050545] Disease Ontology: DOID:0050545 OMIM: 613751 Orphanet: ORPHA157769