anti-Mullerian hormone receptor type 2 | Type II receptor serine/threonine kinases | IUPHAR/BPS Guide to PHARMACOLOGY

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anti-Mullerian hormone receptor type 2

Target not currently curated in GtoImmuPdb

Target id: 1793

Nomenclature: anti-Mullerian hormone receptor type 2

Abbreviated Name: MISR2

Family: Type II receptor serine/threonine kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Anti-Müllerian hormone receptors
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 478 12q13 AMHR2 anti-Mullerian hormone receptor type 2
Mouse 1 568 15 Amhr2 anti-Mullerian hormone type 2 receptor
Rat 1 557 7q36 Amhr2 anti-Mullerian hormone receptor type 2
Previous and Unofficial Names
AMH type II receptor | anti-Mullerian hormone type 2 receptor | MIS type II receptor | MISIIR | MISR2 | anti-Mullerian hormone receptor type II | anti-Mullerian hormone receptor
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.30
Natural/Endogenous Ligands
Müllerian inhibiting substance {Sp: Human}
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004256 abnormal maternal decidual layer morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001930 abnormal meiosis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008256 abnormal myometrium morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001928 abnormal ovulation PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001712 abnormal placenta development PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008803 abnormal placental labyrinth vasculature morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0002216 abnormal seminiferous tubule morphology PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002216 abnormal seminiferous tubule morphology PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008959 abnormal spongiotrophoblast cell morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004244 abnormal spontaneous abortion rate PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0006418 abnormal testis cord formation PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0003830 abnormal testis development PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004014 abnormal uterine environment PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001134 absent corpus luteum PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0003403 absent placental labyrinth PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0003379 absent sexual maturation PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0008261 arrest of male meiosis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001155 arrest of spermatogenesis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001155 arrest of spermatogenesis PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0005159 azoospermia PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002286 cryptorchism PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0002780 decreased circulating testosterone level PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002780 decreased circulating testosterone level PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002682 decreased mature ovarian follicle number PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001785 edema PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008762 embryonic lethality PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001926 female infertility PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001914 hemorrhage PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001729 impaired embryo implantation PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0009397 increased trophoblast giant cell number PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0009207 internal male genitalia hypoplasia PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001925 male infertility PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001925 male infertility PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0009444 ovarian follicular cyst PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0004834 ovary hemorrhage PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0005158 ovary hypoplasia PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001923 reduced female fertility PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0009089 short uterine horn PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002768 small adrenal glands PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001153 small seminiferous tubules PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001147 small testis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001147 small testis PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001940 testicular hypoplasia PMID: 15118069 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Persistent Mullerian duct syndrome, types I and II
OMIM: 261550
Orphanet: ORPHA2856

How to cite this page

Type II receptor serine/threonine kinases: anti-Mullerian hormone receptor type 2. Last modified on 30/07/2019. Accessed on 15/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1793.