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anti-Mullerian hormone receptor type 2

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Target not currently curated in GtoImmuPdb

Target id: 1793

Nomenclature: anti-Mullerian hormone receptor type 2

Abbreviated Name: MISR2

Family: Type II receptor serine/threonine kinases

Quaternary Structure: Complexes
Anti-Müllerian hormone receptors
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 573 12q13.13 AMHR2 anti-Mullerian hormone receptor type 2
Mouse 1 568 15 57.58 cM Amhr2 anti-Mullerian hormone type 2 receptor
Rat 1 557 7q36 Amhr2 anti-Mullerian hormone receptor type 2
Previous and Unofficial Names Click here for help
AMH type II receptor | anti-Mullerian hormone type 2 receptor | MIS type II receptor | MISIIR | MISR2 | anti-Mullerian hormone receptor type II | anti-Mullerian hormone receptor
Database Links Click here for help
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.30
Natural/Endogenous Ligands Click here for help
Müllerian inhibiting substance {Sp: Human}
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004256 abnormal maternal decidual layer morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001930 abnormal meiosis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008256 abnormal myometrium morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001928 abnormal ovulation PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001712 abnormal placenta development PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008803 abnormal placental labyrinth vasculature morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0002216 abnormal seminiferous tubule morphology PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002216 abnormal seminiferous tubule morphology PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008959 abnormal spongiotrophoblast cell morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004244 abnormal spontaneous abortion rate PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0006418 abnormal testis cord formation PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0003830 abnormal testis development PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004014 abnormal uterine environment PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001134 absent corpus luteum PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0003403 absent placental labyrinth PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0003379 absent sexual maturation PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0008261 arrest of male meiosis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001155 arrest of spermatogenesis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001155 arrest of spermatogenesis PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0005159 azoospermia PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002286 cryptorchism PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0002780 decreased circulating testosterone level PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002780 decreased circulating testosterone level PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002682 decreased mature ovarian follicle number PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001785 edema PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008762 embryonic lethality PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001926 female infertility PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001914 hemorrhage PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001729 impaired embryo implantation PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0009397 increased trophoblast giant cell number PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0009207 internal male genitalia hypoplasia PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001925 male infertility PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001925 male infertility PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0009444 ovarian follicular cyst PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0004834 ovary hemorrhage PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0005158 ovary hypoplasia PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001923 reduced female fertility PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0009089 short uterine horn PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0002768 small adrenal glands PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001153 small seminiferous tubules PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Artm1Chc Amhr2tm3(cre)Bhr/Amhr2+,Artm1Chc/Y
involves: 129S/SvEv * C57BL/6
MGI:105062  MGI:88064  MP:0001147 small testis PMID: 17142319 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001147 small testis PMID: 15118069 
Amhr2+|Amhr2tm3(cre)Bhr|Nr5a1tm1Klp|Nr5a1tm2Klp Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd
MGI:105062  MGI:1346833  MP:0001940 testicular hypoplasia PMID: 15118069 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Persistent Mullerian duct syndrome, types I and II
OMIM: 261550
Orphanet: ORPHA2856

How to cite this page

Type II receptor serine/threonine kinases: anti-Mullerian hormone receptor type 2. Last modified on 30/07/2019. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1793.