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RTP Type D

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Target not currently curated in GtoImmuPdb

Target id: 1853

Nomenclature: RTP Type D

Family: Receptor tyrosine phosphatase (RTP) family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1912 9p24.1-p23 PTPRD protein tyrosine phosphatase receptor type D
Mouse 1 1912 4 36.94 cM Ptprd protein tyrosine phosphatase receptor type D
Rat - - Ptprd protein tyrosine phosphatase, receptor type, D
Previous and Unofficial Names Click here for help
HPTP | protein tyrosine phosphatase, receptor type, D | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type D
Database Links Click here for help
Alphafold
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
7-BIA Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 5.5 – 6.0 pIC50 1
pIC50 5.5 – 6.0 (IC50 3x10-6 – 1x10-6 M) [1]
Description: Inhibition of p-nitrophenyl phosphate dephosphorylation by recombinant PTPRD phosphatase domain fusion protein following 16-18 minute preincubation.
Immuno Process Associations
Immuno Process:  Immune regulation
Physiological Consequences of Altering Gene Expression Click here for help
Heterozygous mouse Ptprd knockouts (i.e. mice with reduced Ptprd expression) show reduced addictive behaviour in cocaine self-administration experiments than their wild-type littermates.
Species:  Mouse
Tissue: 
Technique: 
References:  1
General Comments
PTPRD is being investigated as a target for the development of antiaddiction therapeutics [1].

References

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1. Uhl GR, Martinez MJ, Paik P, Sulima A, Bi GH, Iyer MR, Gardner E, Rice KC, Xi ZX. (2018) Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci USA, 115 (45): 11597-11602. [PMID:30348770]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type D. Last modified on 24/10/2018. Accessed on 16/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1853.