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RTP Type D

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Target not currently curated in GtoImmuPdb

Target id: 1853

Nomenclature: RTP Type D

Family: Receptor tyrosine phosphatase (RTP) family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1912 9p24.1-p23 PTPRD protein tyrosine phosphatase receptor type D
Mouse 1 1912 4 36.94 cM Ptprd protein tyrosine phosphatase, receptor type, D
Rat - - Ptprd protein tyrosine phosphatase, receptor type, D
Previous and Unofficial Names Click here for help
HPTP | protein tyrosine phosphatase, receptor type, D | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type D
Database Links Click here for help
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
7-BIA Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 5.5 – 6.0 pIC50 1
pIC50 5.5 – 6.0 (IC50 3x10-6 – 1x10-6 M) [1]
Description: Inhibition of p-nitrophenyl phosphate dephosphorylation by recombinant PTPRD phosphatase domain fusion protein following 16-18 minute preincubation.
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050776 regulation of immune response IMP
Physiological Consequences of Altering Gene Expression Click here for help
Heterozygous mouse Ptprd knockouts (i.e. mice with reduced Ptprd expression) show reduced addictive behaviour in cocaine self-administration experiments than their wild-type littermates.
Species:  Mouse
Tissue: 
Technique: 
References:  1
General Comments
PTPRD is being investigated as a target for the development of antiaddiction therapeutics [1].

References

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1. Uhl GR, Martinez MJ, Paik P, Sulima A, Bi GH, Iyer MR, Gardner E, Rice KC, Xi ZX. (2018) Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci USA, 115 (45): 11597-11602. [PMID:30348770]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type D. Last modified on 24/10/2018. Accessed on 15/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1853.