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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 1907 | 1p34.2 | PTPRF | protein tyrosine phosphatase receptor type F | |
| Mouse | 1 | 1898 | 4 D2.1 | Ptprf | protein tyrosine phosphatase receptor type F | |
| Rat | 1 | 1898 | 5q36 | Ptprf | protein tyrosine phosphatase, receptor type, F | |
| Previous and Unofficial Names |
| LARFN5C | leukocyte antigen-related (LAR) PTP receptor | protein tyrosine phosphatase, receptor type, F | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type F |
| Database Links |
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| Alphafold | P10586 (Hs), A2A8L5 (Mm), Q64604 (Rn) |
| CATH/Gene3D | 3.90.190.10, 2.60.40.10 |
| ChEMBL Target | CHEMBL3521 (Hs), CHEMBL2834 (Rn) |
| Ensembl Gene | ENSG00000142949 (Hs), ENSMUSG00000033295 (Mm), ENSRNOG00000019977 (Rn) |
| Entrez Gene | 5792 (Hs), 19268 (Mm), 360406 (Rn) |
| Human Protein Atlas | ENSG00000142949 (Hs) |
| KEGG Gene | hsa:5792 (Hs), mmu:19268 (Mm), rno:360406 (Rn) |
| OMIM | 179590 (Hs) |
| Pharos | P10586 (Hs) |
| UniProtKB | P10586 (Hs), A2A8L5 (Mm), Q64604 (Rn) |
| Wikipedia | PTPRF (Hs) |
| Putative endogenous ligands |
| netrin-G3 ligand (LRRC4B, Q9NT99) [1] |
Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Immuno Process Associations | ||
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1. Kwon SK, Woo J, Kim SY, Kim H, Kim E. (2010) Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. J Biol Chem, 285 (18): 13966-78. [PMID:20139422]
2. Ling Q, Huang Y, Zhou Y, Cai Z, Xiong B, Zhang Y, Ma L, Wang X, Li X, Li J et al.. (2008) Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem, 16 (15): 7399-409. [PMID:18579388]
Receptor tyrosine phosphatase (RTP) family: RTP Type F. Last modified on 15/09/2015. Accessed on 23/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1855.
