CD27 | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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CD27

target has curated data in GtoImmuPdb

Target id: 1876

Nomenclature: CD27

Systematic Nomenclature: TNFRSF7

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 260 12p13.31 CD27 CD27 molecule
Mouse 1 250 Cd27 CD27 antigen
Rat - - Cd27 CD27 molecule
Previous and Unofficial Names
CD antigen 27 | CD27 molecule | Tp55
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
CD70 {Sp: Human}
Adaptor proteins (Human)
TRAF2, SIVA
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CD70 {Sp: Human} Hs - - -
Immunopharmacology Comments
CD27 (TNFRSF7) is a co-stimulatory immune checkpoint molecule that is expressed on various immune cells, including T cells and NK (natural killer) cells. The endogenous ligand for CD27 is CD70. CD27 interacts with various TRAF adaptor proteins and apoptosis regulatory protein SIVA (SIVA1). It has been recognized as playing an important role in priming, enhancing and sustaining a productive anti-cancer (CD8 T cell) adaptive immune response. CD27 is an immuno-oncology target [1-2]. The agonistic CD27 antibody varlilumab (CDX-1127) is being evaluated for efficacy against solid cancers and lymphomas in early phase clinical trials. Click here to link to ClinicalTrials.gov's list of registered varlilumab trials.
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0016064 immunoglobulin mediated immune response NAS
GO:0070233 negative regulation of T cell apoptotic process IBA
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GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0016064 immunoglobulin mediated immune response NAS
GO:0042100 B cell proliferation NAS
GO:0045579 positive regulation of B cell differentiation NAS
GO:0048305 immunoglobulin secretion NAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0045579 positive regulation of B cell differentiation NAS
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0045579 positive regulation of B cell differentiation NAS
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0045078 positive regulation of interferon-gamma biosynthetic process NAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0042100 B cell proliferation NAS
GO:0045579 positive regulation of B cell differentiation NAS
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045582 positive regulation of T cell differentiation IEA

References

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1. Buchan SL, Rogel A, Al-Shamkhani A. (2018) The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood, 131 (1): 39-48. [PMID:29118006]

2. van de Ven K, Borst J. (2015) Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential. Immunotherapy, 7 (6): 655-67. [PMID:26098609]

Contributors

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