ADGRF1 | Adhesion Class GPCRs | IUPHAR/BPS Guide to PHARMACOLOGY

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ADGRF1

Target not currently curated in GtoImmuPdb

Target id: 190

Nomenclature: ADGRF1

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 911 6p12.3 ADGRF1 adhesion G protein-coupled receptor F1 2
Mouse 7 908 17 B3 Adgrf1 adhesion G protein-coupled receptor F1
Rat 7 909 9q12 Adgrf1 adhesion G protein-coupled receptor F1
Previous and Unofficial Names
GPR110 (G protein-coupled receptor 110)
Database Links
Specialist databases
GPCRDB agrf1_human (Hs), agrf1_mouse (Mm)
Other databases
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Unigene expression profile: high frequency in trachea, mouth, kidney, lung, prostate.
Species:  Human
Technique: 
References: 
Kidney and prostate, overexpressed in lung and prostate tumors, present in lung cancer cell lines (A549, H460, H23) and the prostate cell line PC-3
Species:  Human
Technique:  RT-PCR and immunohistochemistry
References:  4
Peripheral blood cells/bone marrow of pediatric B-precursor acute lymphoblastic leukemia patients
Species:  Human
Technique:  Microarray analysis
References:  3
Spleen, T lymphomas
Species:  Mouse
Technique:  RT-PCR
References:  4
Liver, kidney (renal pelvis), adrenal gland
Species:  Mouse
Technique:  RT-PCR and LacZ insertion
References:  5
Unigene expression profile: high frequency in the eye.
Species:  Rat
Technique: 
References: 
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
ADGRF1 (formerly GPR110) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF2-5 (formerly GPR111, GPR113, GPR115 and GPR116 respectively) [1]. The genes of Family VI Adhesion-GPCRs except ADGRF3 are syntenically clustered on human chromosome 6 and mouse chromosome 17 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [5].

References

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1. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun., 301 (3): 725-34. [PMID:12565841]

2. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett., 531 (3): 407-14. [PMID:12435584]

3. Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, Chen IM, Atlas SR, Kang H, Ar K et al.. (2010) Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood, 116 (23): 4874-84. [PMID:20699438]

4. Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N, Wabl M. (2010) Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. BMC Cancer, 10: 40. [PMID:20149256]

5. Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP et al.. (2012) Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev. Dyn., 241 (10): 1591-602. [PMID:22837050]

Contributors

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