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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 910 | 6p12.3 | ADGRF1 | adhesion G protein-coupled receptor F1 | 3 |
| Mouse | 7 | 908 | 17 B3 | Adgrf1 | adhesion G protein-coupled receptor F1 | |
| Rat | 7 | 909 | 9q12 | Adgrf1 | adhesion G protein-coupled receptor F1 | |
| Previous and Unofficial Names |
| GPR110 (G protein-coupled receptor 110) | PGR19 |
| Database Links |
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| Specialist databases | |
| GPCRdb | agrf1_human (Hs), agrf1_mouse (Mm) |
| Other databases | |
| Alphafold | Q5T601 (Hs), Q8VEC3 (Mm) |
| CATH/Gene3D | 3.30.70.960 |
| ChEMBL Target | CHEMBL4523872 (Hs) |
| Ensembl Gene | ENSG00000153292 (Hs), ENSMUSG00000041293 (Mm), ENSRNOG00000062544 (Rn) |
| Entrez Gene | 266977 (Hs), 77596 (Mm), 301266 (Rn) |
| Human Protein Atlas | ENSG00000153292 (Hs) |
| KEGG Gene | hsa:266977 (Hs), mmu:77596 (Mm), rno:301266 (Rn) |
| Pharos | Q5T601 (Hs) |
| RefSeq Nucleotide | NM_153840 (Hs), NM_133776 (Mm) |
| RefSeq Protein | NP_722582 (Hs), NP_598537 (Mm) |
| UniProtKB | Q5T601 (Hs), Q8VEC3 (Mm) |
| Wikipedia | ADGRF1 (Hs) |
| Endogenous agonists |
| Peptides derived from the Stachel sequence TSFSILMSPFVPSTIFPVVKWIT [1,8] |
| Agonist Comments | ||
| N-docosahexaenoylethanolamine (synaptamide) is an ADGRF1 agonist [5], as are peptides derived from the Stachel sequence TSFSILMSPFVPSTIFPVVKWIT [1,8]. |
| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gs family | |
| References: 1,5 | |
| Secondary Transduction Mechanisms |
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| Transducer | Effector/Response |
| Gq/G11 family | |
| References: 1,8 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| General Comments |
| ADGRF1 (formerly GPR110) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF2-5 (formerly GPR111, GPR113, GPR115 and GPR116 respectively) [2]. The genes of Family VI Adhesion-GPCRs except ADGRF3 are syntenically clustered on human chromosome 6 and mouse chromosome 17 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [7]. The N terminus of ADGRF1 contains a GPCR proteolysis site (GPS) and a SEA (Sperm protein, Enterokinase and Agrin) domain. ADGRF1 is a receptor for N-docosahexaenoylethanolamine (synaptamide), an endogenous metabolite of docosahexaenoic acid, that potently promotes neurogenesis, neuritogenesis and synaptogenesis. ADGRF1 knockout mice show significant deficits in object recognition and spatial memory [5]. |
1. Demberg LM, Winkler J, Wilde C, Simon KU, Schön J, Rothemund S, Schöneberg T, Prömel S, Liebscher I. (2017) Activation of Adhesion G Protein-coupled Receptors: AGONIST SPECIFICITY OF STACHEL SEQUENCE-DERIVED PEPTIDES. J Biol Chem, 292 (11): 4383-4394. [PMID:28154189]
2. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]
3. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531 (3): 407-14. [PMID:12435584]
4. Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, Chen IM, Atlas SR, Kang H, Ar K et al.. (2010) Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood, 116 (23): 4874-84. [PMID:20699438]
5. Lee JW, Huang BX, Kwon H, Rashid MA, Kharebava G, Desai A, Patnaik S, Marugan J, Kim HY. (2016) Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function. Nat Commun, 7: 13123. [PMID:27759003]
6. Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N, Wabl M. (2010) Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. BMC Cancer, 10: 40. [PMID:20149256]
7. Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP et al.. (2012) Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn, 241 (10): 1591-602. [PMID:22837050]
8. Stoveken HM, Hajduczok AG, Xu L, Tall GG. (2015) Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist. Proc Natl Acad Sci USA, 112 (19): 6194-9. [PMID:25918380]
