KCTD8

Target id: 1917

Nomenclature: KCTD8

Quaternary Structure: Complexes
GABA_B receptor

Gene and Protein Information

Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	References
Human	-	473	4p13	KCTD8	potassium channel tetramerization domain containing 8	1
Mouse	-	476	5 C3	Kctd8	potassium channel tetramerisation domain containing 8	1
Rat	-	476	14p11	Kctd8	potassium channel tetramerization domain containing 8	1

Previous and Unofficial Names
BTB/POZ domain-containing protein KCTD8

Previous and Unofficial Names

BTB/POZ domain-containing protein KCTD8

Database Links
Alphafold	Q6ZWB6 (Hs), Q50H33 (Mm)
ChEMBL Target	CHEMBL4523356 (Hs), CHEMBL4523317 (Mm)
Ensembl Gene	ENSG00000183783 (Hs), ENSMUSG00000037653 (Mm), ENSRNOG00000063710 (Rn)
Entrez Gene	386617 (Hs), 243043 (Mm), 364148 (Rn)
Human Protein Atlas	ENSG00000183783 (Hs)
KEGG Gene	hsa:386617 (Hs), mmu:243043 (Mm), rno:364148 (Rn)
Pharos	Q6ZWB6 (Hs)
RefSeq Nucleotide	NM_198353 (Hs), NM_175519 (Mm), NM_001100172 (Rn)
RefSeq Protein	NP_938167 (Hs), NP_780728 (Mm), NP_001093642 (Rn)
UniProtKB	Q6ZWB6 (Hs), Q50H33 (Mm)
Wikipedia	KCTD8 (Hs)

Protein Comments
KCTD proteins act as auxiliary subunits of GABA_B receptors that determine the pharmacology and kinetics of the receptor response. GABA_B receptors assemble from principle and auxiliary subunits. The principle subunits GABA_B1 and GABA_B2 form functional heteromeric GABA_B(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

Protein Comments

KCTD proteins act as auxiliary subunits of GABA_B receptors that determine the pharmacology and kinetics of the receptor response. GABA_B receptors assemble from principle and auxiliary subunits. The principle subunits GABA_B1 and GABA_B2 form functional heteromeric GABA_B(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

References

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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J Biol Chem, 287 (47): 39869-77. [PMID:23035119]