Target id: 1917

Nomenclature: KCTD8

Quaternary Structure: Complexes
GABAB receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human - 473 4p13 KCTD8 potassium channel tetramerization domain containing 8 1
Mouse - 476 5 C3 Kctd8 potassium channel tetramerisation domain containing 8 1
Rat - 476 14p11 Kctd8 potassium channel tetramerization domain containing 8 1
Previous and Unofficial Names
BTB/POZ domain-containing protein KCTD8
Database Links
Alphafold Q6ZWB6 (Hs), Q50H33 (Mm)
ChEMBL Target CHEMBL4523356 (Hs), CHEMBL4523317 (Mm)
Ensembl Gene ENSG00000183783 (Hs), ENSMUSG00000037653 (Mm), ENSRNOG00000063710 (Rn)
Entrez Gene 386617 (Hs), 243043 (Mm), 364148 (Rn)
Human Protein Atlas ENSG00000183783 (Hs)
KEGG Gene hsa:386617 (Hs), mmu:243043 (Mm), rno:364148 (Rn)
Pharos Q6ZWB6 (Hs)
RefSeq Nucleotide NM_198353 (Hs), NM_175519 (Mm), NM_001100172 (Rn)
RefSeq Protein NP_938167 (Hs), NP_780728 (Mm), NP_001093642 (Rn)
UniProtKB Q6ZWB6 (Hs), Q50H33 (Mm)
Wikipedia KCTD8 (Hs)
Protein Comments
KCTD proteins act as auxiliary subunits of GABAB receptors that determine the pharmacology and kinetics of the receptor response. GABAB receptors assemble from principle and auxiliary subunits. The principle subunits GABAB1 and GABAB2 form functional heteromeric GABAB(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].


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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J Biol Chem, 287 (47): 39869-77. [PMID:23035119]

How to cite this page

KCTD8. Last modified on 18/08/2014. Accessed on 28/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1917.