Target id: 1918

Nomenclature: KCTD12

Quaternary Structure: Complexes
GABAB receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human - 325 13q21 KCTD12 potassium channel tetramerization domain containing 12 1
Mouse - 327 14 E2 Kctd12 potassium channel tetramerisation domain containing 12 1
Rat - - 15q22 Kctd12 potassium channel tetramerization domain containing 12 1
Previous and Unofficial Names
Database Links
Ensembl Gene ENSG00000178695 (Hs), ENSMUSG00000048107 (Mm), ENSRNOG00000024294 (Rn)
Entrez Gene 115207 (Hs), 239217 (Mm), 364458 (Rn)
Human Protein Atlas ENSG00000178695 (Hs)
KEGG Gene hsa:115207 (Hs), mmu:239217 (Mm), rno:364458 (Rn)
OMIM 610521 (Hs)
Pharos Q96CX2 (Hs)
RefSeq Nucleotide NM_138444 (Hs), NM_177715 (Mm)
RefSeq Protein NP_612453 (Hs), NP_808383 (Mm)
UniProtKB Q96CX2 (Hs), Q6WVG3 (Mm)
Wikipedia KCTD12 (Hs)
Protein Comments
KCTD proteins act as auxiliary subunits of GABAB receptors that determine the pharmacology and kinetics of the receptor response. GABAB receptors assemble from principle and auxiliary subunits. The principle subunits GABAB1 and GABAB2 form functional heteromeric GABAB(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].


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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J. Biol. Chem., 287 (47): 39869-77. [PMID:23035119]

How to cite this page

KCTD12. Last modified on 01/08/2014. Accessed on 25/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1918.