Target id: 1919

Nomenclature: kctd12b

Quaternary Structure: Complexes
GABAB receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Mouse - 292 X F3 Kctd12b potassium channel tetramerisation domain containing 12b 1
Database Links
Ensembl Gene ENSMUSG00000041633 (Mm)
Entrez Gene 207474 (Mm)
KEGG Gene mmu:207474 (Mm)
RefSeq Nucleotide NM_175429 (Mm)
RefSeq Protein NP_780638 (Mm)
UniProtKB Q8C7J6 (Mm)
Protein Comments
KCTD proteins act as auxiliary subunits of GABAB receptors that determine the pharmacology and kinetics of the receptor response. GABAB receptors assemble from principle and auxiliary subunits. The principle subunits GABAB1 and GABAB2 form functional heteromeric GABAB(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].


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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J. Biol. Chem., 287 (47): 39869-77. [PMID:23035119]

How to cite this page

kctd12b. Last modified on 02/03/2017. Accessed on 04/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1919.