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Target not currently curated in GtoImmuPdb

Target id: 192

Nomenclature: ADGRG4

Family: Adhesion Class GPCRs

Gene and Protein Information Click here for help
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 3080 Xq26.3 ADGRG4 adhesion G protein-coupled receptor G4
Mouse 7 3073 X A6 Adgrg4 adhesion G protein-coupled receptor G4
Rat 7 2823 Xq36 Gpr112l G protein-coupled receptor 112-like
Previous and Unofficial Names Click here for help
GPR112 (G protein-coupled receptor 112)
Database Links Click here for help
Specialist databases
GPCRdb agrg4_human (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution Click here for help
Mammary gland, kidney, blood vessel, retina, testis
Species:  Human
Technique:  Microarray analysis and EST
References:  1,3,5
Enterochromaffin cells of normal ileal mucosa, upregulated in related primary neuroendocrine carcinoma and liver metastasis
Species:  Human
Technique:  Microarray analysis and RT-PCR
References:  5
Unigene expression profile: kidney and embryonic carcinoma.
Species:  Mouse
Mucosal layers of gastrointestinal tract, with highest level of expression in the duodenum
Species:  Mouse
Technique:  RT-PCR
References:  4
General Comments
ADGRG4 (formerly GPR112) is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with ADGRG1-3 and ADGRG5-7 [2]. ADGRG4 was found to contain a laminin_G/pentraxin (PTX) domain along with the GPS motif.

The original gene prediction [3] failed to predict the first and last coding exons.

There are five well characterised amino acid-changing SNPs as well as a number of reported amino acid-changing SNPs which are not confirmed.

Mouse RefSeq NM_001033327.1 is based on cDNAs which cover only the last 5 exons.


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1. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MA, Fredriksson R, Schiöth HB. (2007) Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene, 387 (1-2): 38-48. [PMID:17056209]

2. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]

3. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531 (3): 407-14. [PMID:12435584]

4. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res, 338 (2): 257-69. [PMID:19763624]

5. Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V. (2009) Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. Mod Pathol, 22 (2): 261-72. [PMID:18953328]


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