KCTD16

Target id: 1920

Nomenclature: KCTD16

Quaternary Structure: Complexes
GABA_B receptor

Gene and Protein Information

Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	References
Human	-	428	5q32	KCTD16	potassium channel tetramerization domain containing 16	1
Mouse	-	427	18 B3	Kctd16	potassium channel tetramerisation domain containing 16	1
Rat	-	418	18p11	Kctd16	potassium channel tetramerization domain containing 16	1

Previous and Unofficial Names
potassium channel tetramerisation domain containing 16

Previous and Unofficial Names

potassium channel tetramerisation domain containing 16

Database Links
Alphafold	Q68DU8 (Hs), Q5DTY9 (Mm)
ChEMBL Target	CHEMBL4523340 (Hs), CHEMBL4523323 (Mm)
Ensembl Gene	ENSG00000183775 (Hs), ENSMUSG00000051401 (Mm), ENSRNOG00000069221 (Rn)
Entrez Gene	57528 (Hs), 383348 (Mm), 291618 (Rn)
Human Protein Atlas	ENSG00000183775 (Hs)
KEGG Gene	hsa:57528 (Hs), mmu:383348 (Mm), rno:291618 (Rn)
OMIM	613423 (Hs)
Pharos	Q68DU8 (Hs)
RefSeq Nucleotide	NM_020768 (Hs), NM_026135 (Mm), NM_001172155 (Rn)
RefSeq Protein	NP_065819 (Hs), NP_080411 (Mm), NP_001165626 (Rn)
UniProtKB	Q68DU8 (Hs), Q5DTY9 (Mm)
Wikipedia	KCTD16 (Hs)

Protein Comments
KCTD proteins act as auxiliary subunits of GABA_B receptors that determine the pharmacology and kinetics of the receptor response. GABA_B receptors assemble from principle and auxiliary subunits. The principle subunits GABA_B1 and GABA_B2 form functional heteromeric GABA_B(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

Protein Comments

KCTD proteins act as auxiliary subunits of GABA_B receptors that determine the pharmacology and kinetics of the receptor response. GABA_B receptors assemble from principle and auxiliary subunits. The principle subunits GABA_B1 and GABA_B2 form functional heteromeric GABA_B(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

References

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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J Biol Chem, 287 (47): 39869-77. [PMID:23035119]