KCTD16

Target id: 1920

Nomenclature: KCTD16

Quaternary Structure: Complexes
GABAB receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human - 428 5q32 KCTD16 potassium channel tetramerization domain containing 16 1
Mouse - 427 18 B3 Kctd16 potassium channel tetramerisation domain containing 16 1
Rat - 418 18p11 Kctd16 potassium channel tetramerization domain containing 16 1
Previous and Unofficial Names
potassium channel tetramerisation domain containing 16
Database Links
Ensembl Gene ENSG00000183775 (Hs), ENSMUSG00000051401 (Mm), ENSRNOG00000021008 (Rn)
Entrez Gene 57528 (Hs), 383348 (Mm), 291618 (Rn)
Human Protein Atlas ENSG00000183775 (Hs)
KEGG Gene hsa:57528 (Hs), mmu:383348 (Mm), rno:291618 (Rn)
OMIM 613423 (Hs)
RefSeq Nucleotide NM_020768 (Hs), NM_026135 (Mm), NM_001172155 (Rn)
RefSeq Protein NP_065819 (Hs), NP_080411 (Mm), NP_001165626 (Rn)
UniProtKB Q68DU8 (Hs), Q5DTY9 (Mm)
Wikipedia KCTD16 (Hs)
Protein Comments
KCTD proteins act as auxiliary subunits of GABAB receptors that determine the pharmacology and kinetics of the receptor response. GABAB receptors assemble from principle and auxiliary subunits. The principle subunits GABAB1 and GABAB2 form functional heteromeric GABAB(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2].

References

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1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]

2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J. Biol. Chem., 287 (47): 39869-77. [PMID:23035119]

How to cite this page

KCTD16. Last modified on 09/12/2013. Accessed on 29/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1920.