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ankyrin repeat and kinase domain containing 1

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Target not currently curated in GtoImmuPdb

Target id: 1932

Nomenclature: ankyrin repeat and kinase domain containing 1

Abbreviated Name: SgK288

Family: Receptor interacting protein kinase (RIPK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 765 11q23.2 ANKK1 ankyrin repeat and kinase domain containing 1
Mouse - 745 9 A5.3 Ankk1 ankyrin repeat and kinase domain containing 1
Rat - - 8 q23 Ankk1 ankyrin repeat and kinase domain containing 1
Previous and Unofficial Names Click here for help
X-kinase | Protein kinase PKK2 | Sugen kinase 288
Database Links Click here for help
Alphafold Q8NFD2 (Hs), Q8BZ25 (Mm)
BRENDA 2.7.11.1
CATH/Gene3D 1.25.40.20
ChEMBL Target CHEMBL5547 (Hs)
Ensembl Gene ENSG00000170209 (Hs), ENSMUSG00000032257 (Mm), ENSRNOG00000025037 (Rn)
Entrez Gene 255239 (Hs), 244859 (Mm), 367080 (Rn)
Human Protein Atlas ENSG00000170209 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:255239 (Hs), mmu:244859 (Mm), rno:367080 (Rn)
OMIM 608774 (Hs)
Pharos Q8NFD2 (Hs)
RefSeq Nucleotide NM_178510 (Hs), NM_172922 (Mm)
RefSeq Protein NP_848605 (Hs), NP_766510 (Mm)
UniProtKB Q8NFD2 (Hs), Q8BZ25 (Mm)
Wikipedia ANKK1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: ANKK1
Ligand Sp. Type Action Value Parameter
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.5 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 7.1 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 7.1 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.8 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.5 pKd
ruxolitinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 6.2 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Receptor interacting protein kinase (RIPK) family: ankyrin repeat and kinase domain containing 1. Last modified on 25/04/2017. Accessed on 04/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1932.