Receptor interacting protein kinases (RIPKs) are a family of serine/threonine and tyrosine kinases with important roles in inflammation and innate immunity. RIPK1 and RIPK3 are critical for the activation of the necroptotic cell death pathway by stimuli such as TNF, interferons and Toll-like receptor ligands [1-3], and they have been implicated in pathologies including stroke, myocardial infarction, retinal injuries, lethal systemic inflammatory response syndrome (SIRS), chronic gut and skin inflammation, and acute pancreatitis.

1. Christofferson DE, Yuan J. (2010) Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol, 22 (2): 263-8. [PMID:20045303]

2. Newton K. (2015) RIPK1 and RIPK3: critical regulators of inflammation and cell death. Trends Cell Biol, 25 (6): 347-53. [PMID:25662614]

3. Vanlangenakker N, Vanden Berghe T, Vandenabeele P. (2012) Many stimuli pull the necrotic trigger, an overview. Cell Death Differ, 19 (1): 75-86. [PMID:22075985]

4. Wada Y, Kondo M, Sakairi K, Nagashima A, Tokita K, Tominaga H, Tomiyama H, Ishikawa T. (2020) Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats. J Pharmacol Exp Ther, 374 (3): 428-437. [PMID:32561685]