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Receptor interacting protein kinase (RIPK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Receptor interacting protein kinases (RIPKs) are a family of serine/threonine and tyrosine kinases with important roles in inflammation and innate immunity. RIPK1 and RIPK3 are critical for the activation of the necroptotic cell death pathway by stimuli such as TNF, interferons and Toll-like receptor ligands [1-3], and they have been implicated in pathologies including stroke, myocardial infarction, retinal injuries, lethal systemic inflammatory response syndrome (SIRS), chronic gut and skin inflammation, and acute pancreatitis.

Enzymes

SgK288 (ankyrin repeat and kinase domain containing 1) Show summary » More detailed page

RIPK1 (receptor interacting serine/threonine kinase 1) Show summary » More detailed page

RIPK2 (receptor interacting serine/threonine kinase 2) Show summary » More detailed page

RIPK3 (receptor interacting serine/threonine kinase 3) Show summary » More detailed page

ANKRD3 (receptor interacting serine/threonine kinase 4) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Receptor interacting protein kinase (RIPK) family. Accessed on 25/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=613.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.