ADGRG5 | Adhesion Class GPCRs | IUPHAR/BPS Guide to PHARMACOLOGY

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ADGRG5

Target not currently curated in GtoImmuPdb

Target id: 194

Nomenclature: ADGRG5

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 528 16q13 ADGRG5 adhesion G protein-coupled receptor G5
Mouse 7 523 8 D1 Adgrg5 adhesion G protein-coupled receptor G5
Rat 7 523 19p13 Adgrg5 adhesion G protein-coupled receptor G5
Previous and Unofficial Names
GPR114 (G protein-coupled receptor 114)
Database Links
Specialist databases
GPCRDB agrg5_human (Hs), agrg5_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Unigene expression profile highest in lymph node, bone marrow, tonsil, thymus, colon, pancreas.
Species:  Human
Technique: 
References: 
Colon, lung, spleen, thymus, pancreas islets of Langerhans, leukocytes, leukemia cells
Species:  Human
Technique:  EST
References:  1-3
Leukocytes
Species:  Human
Technique:  Microarray analysis
References:  7
Unigene expression proifile highest in blood, spleen, inner ear, thymus.
Species:  Mouse
Technique: 
References: 
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Elevated levels of cAMP
Species:  Human
Tissue:  293T cell line
Response measured:  Receptor causes constitutive activation of GαS G protein
References:  5
General Comments
ADGRG5 (formerly GPR114) is an orphan receptor belonging to Family VIII Adhesion-GPCRs together with ADGRG1-4, 6 and 7 [3]. The genes of ADGRG1, ADGRG3 and ADGRG5 are syntenically clustered on human chromosome 16 and mouse chromosome 8 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [7].

Full coding sequence human cDNA is publicly available, IMAGE:5210813 [6], in mammalian expression vector pCMV-SPORT6.

Original human gene prediction, AY140956 [4] incorrectly predicts the 3' end of the gene resulting in a longer protein, (Swiss-Prot ID: Q8IZF4, 570 aa), than the observed cDNAs.

References

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1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]

2. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MA, Fredriksson R, Schiöth HB. (2007) Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene, 387 (1-2): 38-48. [PMID:17056209]

3. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun., 301 (3): 725-34. [PMID:12565841]

4. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett., 531 (3): 407-14. [PMID:12435584]

5. Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X. (2012) Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett., 586 (8): 1214-9. [PMID:22575658]

6. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]

7. Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, Mackay CR, Lin HH, Hamann J. (2011) Specific expression of GPR56 by human cytotoxic lymphocytes. J. Leukoc. Biol., 90 (4): 735-40. [PMID:21724806]

Contributors

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