cyclin dependent kinase 11B | PITSLRE subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin dependent kinase 11B

Target not currently curated in GtoImmuPdb

Target id: 1964

Nomenclature: cyclin dependent kinase 11B

Abbreviated Name: CDK11B

Family: PITSLRE subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 782 1p36.33 CDK11B cyclin dependent kinase 11B
Mouse - 784 4 E2 Cdk11b cyclin-dependent kinase 11B
Rat - 784 5 q36 Cdk11b cyclin-dependent kinase 11B
Previous and Unofficial Names
CDC2L1 | CDK11-p110 | CDK11-p46 | CDK11-p58 | cell division cycle 2-like protein kinase 1 | cell division protein kinase 11 | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLRE serine/threonine-protein kinase CDC2L1CDK11-p110
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CDC2L1
Ligand Sp. Type Action Value Parameter
AT-7519 Hs Inhibitor Inhibition 8.1 pKd
BMS-387032 Hs Inhibitor Inhibition 7.0 pKd
tozasertib Hs Inhibitor Inhibition 6.5 pKd
BMS-345541 Hs Inhibitor Inhibition 6.4 pKd
foretinib Hs Inhibitor Inhibition 6.2 pKd
crizotinib Hs Inhibitor Inhibition 6.1 pKd
barasertib-hQPA Hs Inhibitor Inhibition 5.9 pKd
linifanib Hs Inhibitor Inhibition 5.9 pKd
AST-487 Hs Inhibitor Inhibition 5.8 pKd
pazopanib Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

PITSLRE subfamily: cyclin dependent kinase 11B. Last modified on 19/12/2013. Accessed on 19/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1964.