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Target not currently curated in GtoImmuPdb
Target id: 1969
Nomenclature: cyclin dependent kinase 16
Abbreviated Name: CDK16
Family: TAIRE subfamily
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 496 | Xp11.3 | CDK16 | cyclin dependent kinase 16 | |
Mouse | - | 496 | X 16.18 cM | Cdk16 | cyclin dependent kinase 16 | |
Rat | - | 496 | Xq11 | Cdk16 | cyclin-dependent kinase 16 |
Previous and Unofficial Names |
cell division protein kinase 16 | CRK5 | PCTAIRE protein kinase 1 | PCTAIRE1 |
Database Links | |
Alphafold | Q00536 (Hs), Q04735 (Mm), Q63686 (Rn) |
BRENDA | 2.7.11.22 |
ChEMBL Target | CHEMBL4597 (Hs) |
Ensembl Gene | ENSG00000102225 (Hs), ENSMUSG00000031065 (Mm), ENSRNOG00000008578 (Rn) |
Entrez Gene | 5127 (Hs), 18555 (Mm), 81741 (Rn) |
Human Protein Atlas | ENSG00000102225 (Hs) |
KEGG Enzyme | 2.7.11.22 |
KEGG Gene | hsa:5127 (Hs), mmu:18555 (Mm), rno:81741 (Rn) |
OMIM | 311550 (Hs) |
Pharos | Q00536 (Hs) |
RefSeq Nucleotide | NM_001170460 (Hs), NM_011049 (Mm), NM_001004132 (Rn) |
RefSeq Protein | NP_006192 (Hs), NP_035179 (Mm), NP_001004132 (Rn) |
UniProtKB | Q00536 (Hs), Q04735 (Mm), Q63686 (Rn) |
Wikipedia | CDK16 (Hs) |
Selected 3D Structures | |||||||||||
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Enzyme Reaction | ||||
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DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2 |
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: PCTK1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
TAIRE subfamily: cyclin dependent kinase 16. Last modified on 22/03/2013. Accessed on 11/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1969.