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cyclin-dependent kinase like 4

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Target not currently curated in GtoImmuPdb

Target id: 1985

Nomenclature: cyclin-dependent kinase like 4

Abbreviated Name: CDKL4

Family: Cyclin-dependent kinase-like (CDKL) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 379 2p22.1 CDKL4 cyclin dependent kinase like 4
Mouse - 342 17 E3 Cdkl4 cyclin dependent kinase like 4
Rat - 342 6 q11 Cdkl4 cyclin-dependent kinase-like 4
Database Links Click here for help
Alphafold Q5MAI5 (Hs), Q3TZA2 (Mm)
BRENDA 2.7.11.22
ChEMBL Target CHEMBL4523326 (Hs)
Ensembl Gene ENSG00000205111 (Hs), ENSMUSG00000033966 (Mm), ENSRNOG00000040266 (Rn)
Entrez Gene 344387 (Hs), 381113 (Mm), 503009 (Rn)
Human Protein Atlas ENSG00000205111 (Hs)
KEGG Enzyme 2.7.11.22
KEGG Gene hsa:344387 (Hs), mmu:381113 (Mm), rno:503009 (Rn)
Pharos Q5MAI5 (Hs)
RefSeq Nucleotide NM_001009565 (Hs), NM_001033443 (Mm), XM_001062504 (Rn)
RefSeq Protein NP_001009565 (Hs), NP_001028615 (Mm), XP_001062504 (Rn)
UniProtKB Q5MAI5 (Hs), Q3TZA2 (Mm)
Wikipedia CDKL4 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: CDKL5
Ligand Sp. Type Action Value Parameter
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.8 pKd
AT-7519 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 8.2 pKd
alvocidib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.0 pKd
A-674563 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.7 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Cyclin-dependent kinase-like (CDKL) family: cyclin-dependent kinase like 4. Last modified on 29/01/2016. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1985.