cyclin-dependent kinase like 4 | Cyclin-dependent kinase-like (CDKL) family | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin-dependent kinase like 4

Target not currently curated in GtoImmuPdb

Target id: 1985

Nomenclature: cyclin-dependent kinase like 4

Abbreviated Name: CDKL4

Family: Cyclin-dependent kinase-like (CDKL) family

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 315 2p22.3 CDKL4 cyclin dependent kinase like 4
Mouse - 342 17 E3 Cdkl4 cyclin-dependent kinase-like 4
Rat - 342 6 q11 Cdkl4 cyclin-dependent kinase-like 4
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CDKL5
Ligand Sp. Type Action Value Parameter
BMS-387032 Hs Inhibitor Inhibition 8.8 pKd
AT-7519 Hs Inhibitor Inhibition 8.6 pKd
AST-487 Hs Inhibitor Inhibition 8.2 pKd
alvocidib Hs Inhibitor Inhibition 8.1 pKd
lestaurtinib Hs Inhibitor Inhibition 8.0 pKd
A-674563 Hs Inhibitor Inhibition 6.7 pKd
staurosporine Hs Inhibitor Inhibition 6.5 pKd
foretinib Hs Inhibitor Inhibition 5.6 pKd
tozasertib Hs Inhibitor Inhibition 5.6 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Cyclin-dependent kinase-like (CDKL) family: cyclin-dependent kinase like 4. Last modified on 29/01/2016. Accessed on 29/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1985.