casein kinase 1 alpha 1 like | Casein kinase 1 (CK1) family | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

casein kinase 1 alpha 1 like

Target not currently curated in GtoImmuPdb

Target id: 1996

Nomenclature: casein kinase 1 alpha 1 like

Abbreviated Name: CK1-A2

Family: Casein kinase 1 (CK1) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 337 13q13.2 CSNK1A1L casein kinase 1 alpha 1 like
Previous and Unofficial Names
CKI-alpha-like | casein kinase 1, alpha 1-like
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CSNK1A1L
Ligand Sp. Type Action Value Parameter
staurosporine Hs Inhibitor Inhibition 6.6 pKd
sunitinib Hs Inhibitor Inhibition 6.3 pKd
SU-14813 Hs Inhibitor Inhibition 5.8 pKd
SB203580 Hs Inhibitor Inhibition 5.8 pKd
TG-100-115 Hs Inhibitor Inhibition 5.7 pKd
PP-242 Hs Inhibitor Inhibition 5.7 pKd
alvocidib Hs Inhibitor Inhibition 5.6 pKd
bosutinib Hs Inhibitor Inhibition 5.6 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
erlotinib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

Show »

1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Casein kinase 1 (CK1) family: casein kinase 1 alpha 1 like. Last modified on 29/01/2016. Accessed on 24/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1996.