Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	404	Xp22.2	GPR143	G protein-coupled receptor 143
Mouse	7	405	X 68.46 cM	Gpr143	G protein-coupled receptor 143
Rat	7	405	Xq21	Gpr143	G protein-coupled receptor 143

Previous and Unofficial Names

MOA1 | ocular albinism 1 (Nettleship-Falls) | NYS6 | Ocular albinism type 1 protein

Database Links
Alphafold	P51810 (Hs), P70259 (Mm)
ChEMBL Target	CHEMBL4523867 (Hs)
Ensembl Gene	ENSG00000101850 (Hs), ENSMUSG00000025333 (Mm), ENSRNOG00000003543 (Rn)
Entrez Gene	4935 (Hs), 18241 (Mm), 302619 (Rn)
Human Protein Atlas	ENSG00000101850 (Hs)
KEGG Gene	hsa:4935 (Hs), mmu:18241 (Mm), rno:302619 (Rn)
OMIM	300500 (Hs)
Orphanet	ORPHA122263 (Hs)
Pharos	P51810 (Hs)
RefSeq Nucleotide	NM_000273 (Hs), NM_010951 (Mm), NM_001103958 (Rn)
RefSeq Protein	NP_000264 (Hs), NP_035081 (Mm), NP_001100428 (Rn)
UniProtKB	P51810 (Hs), P70259 (Mm)
Wikipedia	GPR143 (Hs)

Natural/Endogenous Ligands
levodopa

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0005101 abnormal ciliary body pigmentation PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0005199 abnormal iris pigment epithelium PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0005075 abnormal melanosome morphology PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0002864 abnormal ocular fundus morphology PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0001332 abnormal optic nerve innervation PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0005200 abnormal pigment epithelium of the eye PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0005103 abnormal retinal pigmentation PMID: 11092754  Gpr143tm1Inc Gpr143tm1Inc/Y either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:107193  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 11092754

Clinically-Relevant Mutations and Pathophysiology
Disease:  Nystagmus 6, congenital, X-linked; NYS6 Synonyms: Congenital nystagmus [Disease Ontology: DOID:9649] Idiopathic infantile nystagmus [Orphanet: ORPHA651] Disease Ontology: DOID:9649 OMIM: 300814 Orphanet: ORPHA651
Disease:  Ocular albinism, type I; OA1 Synonyms: Ocular albinism [Disease Ontology: DOID:0050633] X-linked recessive ocular albinism [Orphanet: ORPHA54] Disease Ontology: DOID:0050633 OMIM: 300500 Orphanet: ORPHA54

General Comments
GPR143 shows no homology to known G protein-coupled receptors.