Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1210	1p13.2	HIPK1	homeodomain interacting protein kinase 1
Mouse	-	1210	3 F2.2	Hipk1	homeodomain interacting protein kinase 1
Rat	-	1211	2q34	Hipk1	homeodomain interacting protein kinase 1

Previous and Unofficial Names

MYAK | NBAK2 | Nuclear body-associated kinase 2

Database Links
Alphafold	Q86Z02 (Hs), O88904 (Mm), A4L9P5 (Rn)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5427 (Hs)
Ensembl Gene	ENSG00000163349 (Hs), ENSMUSG00000008730 (Mm), ENSRNOG00000019333 (Rn)
Entrez Gene	204851 (Hs), 15257 (Mm), 365895 (Rn)
Human Protein Atlas	ENSG00000163349 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:204851 (Hs), mmu:15257 (Mm), rno:365895 (Rn)
OMIM	608003 (Hs)
Pharos	Q86Z02 (Hs)
RefSeq Nucleotide	NM_198268 (Hs), NM_010432 (Mm), NM_001100986 (Rn)
RefSeq Protein	NP_938009 (Hs), NP_034562 (Mm), NP_001094456 (Rn)
UniProtKB	Q86Z02 (Hs), O88904 (Mm), A4L9P5 (Rn)
Wikipedia	HIPK1 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference staurosporine Hs Inhibition 5.6 pIC50 4 ⤷ pIC50 5.6 (IC50 2.639x10-6 M) [4]

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,5
Key to terms and symbols		Click column headers to sort
Target used in screen: HIPK1
Ligand Sp. Type Action Value Parameter sunitinib Hs Inhibitor Inhibition 7.3 pKd PHA-665752 Hs Inhibitor Inhibition 7.0 pKd AST-487 Hs Inhibitor Inhibition 6.8 pKd ruboxistaurin Hs Inhibitor Inhibition 6.6 pKd A-674563 Hs Inhibitor Inhibition 6.6 pKd PP-242 Hs Inhibitor Inhibition 6.5 pKd foretinib Hs Inhibitor Inhibition 6.4 pKd KW-2449 Hs Inhibitor Inhibition 6.4 pKd GSK690693 Hs Inhibitor Inhibition 6.3 pKd bosutinib Hs Inhibitor Inhibition 6.3 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3
Key to terms and symbols		Click column headers to sort
Target used in screen: HIPK1/HIPK1
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM sunitinib Hs Inhibitor Inhibition 71.3 Gö 6983 Hs Inhibitor Inhibition 77.7 88.0 34.0 Gö 6976 Hs Inhibitor Inhibition 81.1 85.0 77.0 ERK inhibitor III Hs Inhibitor Inhibition 81.1 99.0 100.0 isogranulatimide Hs Inhibitor Inhibition 82.6 77.0 58.0 TWS119 Hs Inhibitor Inhibition 82.7 108.0 87.0 GSK-3 inhibitor X Hs Inhibitor Inhibition 83.0 95.0 85.0 GSK-3 inhibitor XIII Hs Inhibitor Inhibition 84.2 95.0 35.0 JAK inhibitor I Hs Inhibitor Inhibition 88.7 84.0 98.0 Flt-3 inhibitor Hs Inhibitor Inhibition 90.2 99.0 105.0
Displaying the top 10 most potent ligands  View all ligands in screen »

Immuno Process Associations

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling