hormonally up-regulated Neu-associated kinase | HUNK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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hormonally up-regulated Neu-associated kinase

Target not currently curated in GtoImmuPdb

Target id: 2037

Nomenclature: hormonally up-regulated Neu-associated kinase

Abbreviated Name: HUNK

Family: HUNK subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 714 21q22.1 HUNK hormonally up-regulated Neu-associated kinase
Mouse - 714 16 C3.3 Hunk hormonally upregulated Neu-associated kinase
Rat - 714 11 q11 Hunk hormonally upregulated Neu-associated kinase
Previous and Unofficial Names
B19 | Bstk1 | MAK5 | Mak-v
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: HUNK
Ligand Sp. Type Action Value Parameter
SU-14813 Hs Inhibitor Inhibition 8.4 pKd
midostaurin Hs Inhibitor Inhibition 6.6 pKd
NVP-TAE684 Hs Inhibitor Inhibition 6.5 pKd
dovitinib Hs Inhibitor Inhibition 6.4 pKd
KW-2449 Hs Inhibitor Inhibition 6.3 pKd
sunitinib Hs Inhibitor Inhibition 6.3 pKd
lestaurtinib Hs Inhibitor Inhibition 6.2 pKd
staurosporine Hs Inhibitor Inhibition 6.2 pKd
PHA-665752 Hs Inhibitor Inhibition 5.8 pKd
axitinib Hs Inhibitor Inhibition 5.8 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

HUNK subfamily: hormonally up-regulated Neu-associated kinase. Last modified on 18/08/2014. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2037.