NIMA related kinase 5 | NIMA (never in mitosis gene a)- related kinase (NEK) family | IUPHAR/BPS Guide to PHARMACOLOGY

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NIMA related kinase 5

Target not currently curated in GtoImmuPdb

Target id: 2120

Nomenclature: NIMA related kinase 5

Abbreviated Name: NEK5

Family: NIMA (never in mitosis gene a)- related kinase (NEK) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 708 13q14.2 NEK5 NIMA related kinase 5
Mouse - 614 8 A2 Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5
Rat - - 16q12.5 Nek5 NIMA-related kinase 5
Previous and Unofficial Names
NIMA-related kinase 5
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: NEK5
Ligand Sp. Type Action Value Parameter
tamatinib Hs Inhibitor Inhibition 7.9 pKd
fedratinib Hs Inhibitor Inhibition 6.2 pKd
staurosporine Hs Inhibitor Inhibition 6.1 pKd
PD-173955 Hs Inhibitor Inhibition 6.1 pKd
AST-487 Hs Inhibitor Inhibition 6.0 pKd
GSK-461364A Hs Inhibitor Inhibition 6.0 pKd
dovitinib Hs Inhibitor Inhibition 5.6 pKd
KW-2449 Hs Inhibitor Inhibition 5.6 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NIMA (never in mitosis gene a)- related kinase (NEK) family: NIMA related kinase 5. Last modified on 29/01/2016. Accessed on 15/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2120.