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Target not currently curated in GtoImmuPdb
Target id: 2142
Nomenclature: pyruvate dehydrogenase kinase 2
Abbreviated Name: PDHK2
Family: PDHK family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 407 | 17q21.33 | PDK2 | pyruvate dehydrogenase kinase 2 | |
Mouse | - | 407 | 11 59.01 cM | Pdk2 | pyruvate dehydrogenase kinase, isoenzyme 2 | |
Rat | - | 407 | 10q26 | Pdk2 | pyruvate dehydrogenase kinase 2 |
Previous and Unofficial Names ![]() |
pyruvate dehydrogenase kinase, isoenzyme 2 | PDK P45 | pyruvate dehydrogenase kinase |
Database Links ![]() |
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Alphafold | Q15119 (Hs), Q9JK42 (Mm), Q64536 (Rn) |
BRENDA | 2.7.11.2 |
CATH/Gene3D | 1.20.140.20, 3.30.565.10 |
ChEMBL Target | CHEMBL3861 (Hs) |
Ensembl Gene | ENSG00000005882 (Hs), ENSMUSG00000038967 (Mm), ENSRNOG00000004172 (Rn) |
Entrez Gene | 5164 (Hs), 18604 (Mm), 81530 (Rn) |
Human Protein Atlas | ENSG00000005882 (Hs) |
KEGG Enzyme | 2.7.11.2 |
KEGG Gene | hsa:5164 (Hs), mmu:18604 (Mm), rno:81530 (Rn) |
OMIM | 602525 (Hs) |
Pharos | Q15119 (Hs) |
RefSeq Nucleotide | NM_001199898 (Hs), NM_133667 (Mm), NM_030872 (Rn) |
RefSeq Protein | NP_002602 (Hs), NP_598428 (Mm), NP_110499 (Rn) |
UniProtKB | Q15119 (Hs), Q9JK42 (Mm), Q64536 (Rn) |
Wikipedia | PDK2 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Knoers NV, van den Ouweland AM, Verdijk M, Monnens LA, van Oost BA. (1994) Inheritance of mutations in the V2 receptor gene in thirteen families with nephrogenic diabetes insipidus. Kidney Int, 46 (1): 170-6. [PMID:7933835]
2. Moore JD, Staniszewska A, Shaw T, D'Alessandro J, Davis B, Surgenor A, Baker L, Matassova N, Murray J, Macias A et al.. (2014) VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget, 5 (24): 12862-76. [PMID:25404640]
3. Morrell JA, Orme J, Butlin RJ, Roche TE, Mayers RM, Kilgour E. (2003) AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. Biochem Soc Trans, 31: 1168-70. [PMID:14641019]
PDHK family: pyruvate dehydrogenase kinase 2. Last modified on 07/11/2016. Accessed on 15/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2142.