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pregnancy up-regulated nonubiquitous CaM kinase

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Target not currently curated in GtoImmuPdb

Target id: 2172

Nomenclature: pregnancy up-regulated nonubiquitous CaM kinase

Abbreviated Name: CaMK1-beta

Family: CAMK1 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 Xq28 PNCK pregnancy up-regulated nonubiquitous CaM kinase
Mouse - 343 X 37.38 cM Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase
Rat - 343 Xq37 Pnck pregnancy up-regulated nonubiquitous CaM kinase
Previous and Unofficial Names Click here for help
Bstk3 | caM kinase IB | caM-KI beta | Punc | pregnancy up-regulated non-ubiquitously expressed CaM kinase
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.17
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/CAMK1b
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 4.8
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 50.5
K-252a Small molecule or natural product Hs Inhibitor Inhibition 55.7
Syk inhibitor II Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 57.3
Syk inhibitor Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 58.1
SU11652 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 70.5
PDK1/Akt/Flt dual pathway inhibitor Small molecule or natural product Hs Inhibitor Inhibition 83.4
SU9516 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 86.3
VEGF receptor 2 kinase inhibitor I Small molecule or natural product Hs Inhibitor Inhibition 88.6
Cdk1/2 inhibitor III Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 89.1
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]

How to cite this page

CAMK1 family: pregnancy up-regulated nonubiquitous CaM kinase. Last modified on 21/03/2013. Accessed on 23/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2172.