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tripartite motif containing 33

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Target not currently curated in GtoImmuPdb

Target id: 2254

Nomenclature: tripartite motif containing 33

Abbreviated Name: TIF1G

Family: TIF1 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1127 1p13.2 TRIM33 tripartite motif containing 33
Mouse - 1142 3 F2.2 Trim33 tripartite motif-containing 33
Rat - 1144 2q34 Trim33 tripartite motif-containing 33
Previous and Unofficial Names Click here for help
E3 ubiquitin-protein ligase TRIM33 | Ecto | ectodermin | ret-fused gene 7 | RFG7 | TF1G | TIF1GAMMA | transcriptional intermediary factor 1 gamma
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of TRIM33 PHD-Bromo in the free state.
PDB Id:  3U5M
Resolution:  3.08Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-20)K9me3K14ac histone peptide.
PDB Id:  3U5N
Resolution:  1.95Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 6.3.2.-
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0004842 ubiquitin-protein transferase activity TAS
GO:0016567 protein ubiquitination IDA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Thyroid carcinoma, papillary
Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146]
Papillary thyroid carcinoma [Disease Ontology: DOID:3969]
Disease Ontology: DOID:3969
OMIM: 188550
Orphanet: ORPHA146

References

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1. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V et al.. (2011) A poised chromatin platform for TGF-β access to master regulators. Cell, 147 (7): 1511-24. [PMID:22196728]

How to cite this page

TIF1 family: tripartite motif containing 33. Last modified on 18/08/2014. Accessed on 28/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2254.