Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	396	14q32.2	VRK1	VRK serine/threonine kinase 1
Mouse	-	440	12 E-F1	Vrk1	vaccinia related kinase 1
Rat	-	414	6 q32	Vrk1	VRK serine/threonine kinase 1

Database Links
Alphafold	Q99986 (Hs), Q80X41 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL1293199 (Hs)
Ensembl Gene	ENSG00000100749 (Hs), ENSMUSG00000021115 (Mm), ENSRNOG00000005274 (Rn)
Entrez Gene	7443 (Hs), 22367 (Mm), 362779 (Rn)
Human Protein Atlas	ENSG00000100749 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:7443 (Hs), mmu:22367 (Mm), rno:362779 (Rn)
OMIM	602168 (Hs)
Orphanet	ORPHA208345 (Hs)
Pharos	Q99986 (Hs)
RefSeq Nucleotide	NM_003384 (Hs), NM_001029843 (Mm), NM_001012194 (Rn)
RefSeq Protein	NP_003375 (Hs), NP_001025014 (Mm), NP_001012194 (Rn)
UniProtKB	Q99986 (Hs), Q80X41 (Mm)
Wikipedia	VRK1 (Hs)

Selected 3D Structures
	Description:  NMR solution structure of human Vaccinia-Related Kinase 1. PDB Id:  2LAV Resolution:  0.0Å Species:  Human References:  2

Enzyme Reaction
EC Number: 2.7.11.1

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/VRK1
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM PKR inhibitor Hs Inhibitor Inhibition 69.1 Gö 6983 Hs Inhibitor Inhibition 76.7 PDGF receptor tyrosine kinase inhibitor III Hs Inhibitor Inhibition 77.4 isogranulatimide Hs Inhibitor Inhibition 78.1 H-89 Hs Inhibitor Inhibition 80.1 K-252a Hs Inhibitor Inhibition 80.5 PKR inhibitor, negative control Hs Inhibitor Inhibition 80.6 GSK-3 inhibitor X Hs Inhibitor Inhibition 80.7 GSK-3 inhibitor XIII Hs Inhibitor Inhibition 81.0 TWS119 Hs Inhibitor Inhibition 81.6
Displaying the top 10 most potent ligands  View all ligands in screen »

Clinically-Relevant Mutations and Pathophysiology
Disease:  Pontocerebellar hypoplasia type 1A; PCH1A Disease Ontology: DOID:0060265 OMIM: 607596 Orphanet: ORPHA2254