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VRK serine/threonine kinase 3

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Target not currently curated in GtoImmuPdb

Target id: 2277

Nomenclature: VRK serine/threonine kinase 3

Abbreviated Name: VRK3

Family: Vaccina related kinase (VRK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 474 19q13.33 VRK3 VRK serine/threonine kinase 3
Mouse - 453 7 B3 Vrk3 vaccinia related kinase 3
Rat - 453 1 q22 Vrk3 VRK serine/threonine kinase 3
Database Links Click here for help
Alphafold Q8IV63 (Hs), Q8K3G5 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL3430761 (Hs)
Ensembl Gene ENSG00000105053 (Hs), ENSMUSG00000002205 (Mm), ENSRNOG00000026517 (Rn)
Entrez Gene 51231 (Hs), 101568 (Mm), 361565 (Rn)
Human Protein Atlas ENSG00000105053 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:51231 (Hs), mmu:101568 (Mm), rno:361565 (Rn)
Pharos Q8IV63 (Hs)
RefSeq Nucleotide NM_016440 (Hs), NM_133945 (Mm), NM_001005561 (Rn)
RefSeq Protein NP_057524 (Hs), NP_598706 (Mm), NP_001005561 (Rn)
UniProtKB Q8IV63 (Hs), Q8K3G5 (Mm)
Wikipedia VRK3 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of VRK3.
PDB Id:  2JII
Resolution:  2.0Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

References

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1. Scheeff ED, Eswaran J, Bunkoczi G, Knapp S, Manning G. (2009) Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure, 17 (1): 128-38. [PMID:19141289]

How to cite this page

Vaccina related kinase (VRK) family: VRK serine/threonine kinase 3. Last modified on 18/09/2018. Accessed on 29/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2277.