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acylaminoacyl-peptide hydrolase

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Target not currently curated in GtoImmuPdb

Target id: 2328

Nomenclature: acylaminoacyl-peptide hydrolase

Family: S9: Prolyl oligopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 3p21.31 APEH acylaminoacyl-peptide hydrolase
Mouse - 732 9 59.07 cM Apeh acylpeptide hydrolase
Rat - 732 8q32 Apeh acylaminoacyl-peptide hydrolase
Previous and Unofficial Names Click here for help
AARE | acyl-peptide hydrolase | APH | acylamino-acid-releasing enzyme | APEH
Database Links Click here for help
Specialist databases
MEROPS S09.004 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.19.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ARI-3099 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 1
pIC50 7.0 (IC50 1.04x10-7 M) [1]
Description: Substrate (Ac-Ala-AMC) assay.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS

References

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1. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol, 10 (8): 656-63. [PMID:24997602]

How to cite this page

S9: Prolyl oligopeptidase: acylaminoacyl-peptide hydrolase. Last modified on 20/07/2015. Accessed on 25/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2328.