acylaminoacyl-peptide hydrolase | S9: Prolyl oligopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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acylaminoacyl-peptide hydrolase

Target not currently curated in GtoImmuPdb

Target id: 2328

Nomenclature: acylaminoacyl-peptide hydrolase

Family: S9: Prolyl oligopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 3p21 APEH acylaminoacyl-peptide hydrolase
Mouse - 732 9 F2 Apeh acylpeptide hydrolase
Rat - 732 8q32 Apeh acylaminoacyl-peptide hydrolase
Previous and Unofficial Names
AARE | acyl-peptide hydrolase | APH | acylamino-acid-releasing enzyme | APEH
Database Links
Specialist databases
MEROPS S09.004 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ARI-3099 Hs Inhibition 7.0 pIC50 1
pIC50 7.0 (IC50 1.04x10-7 M) [1]
Description: Substrate (Ac-Ala-AMC) assay.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS


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1. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat. Chem. Biol., 10 (8): 656-63. [PMID:24997602]

How to cite this page

S9: Prolyl oligopeptidase: acylaminoacyl-peptide hydrolase. Last modified on 20/07/2015. Accessed on 13/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,