calpain 2 | C2: Calpain | IUPHAR/BPS Guide to PHARMACOLOGY

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calpain 2

Target not currently curated in GtoImmuPdb

Target id: 2337

Nomenclature: calpain 2

Family: C2: Calpain

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 700 1q41-q42 CAPN2 calpain 2
Mouse - 700 1 H5 Capn2 calpain 2
Rat - 700 13q26 Capn2 calpain 2
Previous and Unofficial Names
80 kDa M-calpain subunit | calcium-activated neutral proteinase 2 | CALP80 | calpain M-type | calpain-2 catalytic subunit | CANP 2 | Capa2 | m-calpain | millimolar-calpain | calpain 2, (m/II) large subunit
Database Links
Specialist databases
MEROPS C02.002 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.53

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5a [PMID: 20690647] Pig Inhibition 7.2 pKi 2
pKi 7.2 (Ki 6.8x10-8 M) [2]
compound 19 [PMID: 8831774] Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.5x10-8 M) [1]
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0032675 regulation of interleukin-6 production IEA
GO:0035458 cellular response to interferon-beta IEA

References

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1. Li Z, Ortega-Vilain AC, Patil GS, Chu DL, Foreman JE, Eveleth DD, Powers JC. (1996) Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J. Med. Chem., 39 (20): 4089-98. [PMID:8831774]

2. Ovat A, Li ZZ, Hampton CY, Asress SA, Fernández FM, Glass JD, Powers JC. (2010) Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J. Med. Chem., 53 (17): 6326-36. [PMID:20690647]

How to cite this page

C2: Calpain: calpain 2. Last modified on 29/01/2016. Accessed on 28/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2337.