calpain 2 | C2: Calpain | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

calpain 2

Target not currently curated in GtoImmuPdb

Target id: 2337

Nomenclature: calpain 2

Family: C2: Calpain

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 700 1q41-q42 CAPN2 calpain 2
Mouse - 700 1 H5 Capn2 calpain 2
Rat - 700 13q26 Capn2 calpain 2
Previous and Unofficial Names
80 kDa M-calpain subunit | calcium-activated neutral proteinase 2 | CALP80 | calpain M-type | calpain-2 catalytic subunit | CANP 2 | Capa2 | m-calpain | millimolar-calpain | calpain 2, (m/II) large subunit
Database Links
Specialist databases
MEROPS C02.002 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5a [PMID: 20690647] Pig Inhibition 7.2 pKi 2
pKi 7.2 (Ki 6.8x10-8 M) [2]
compound 19 [PMID: 8831774] Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.5x10-8 M) [1]
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0032675 regulation of interleukin-6 production IEA
GO:0035458 cellular response to interferon-beta IEA


Show »

1. Li Z, Ortega-Vilain AC, Patil GS, Chu DL, Foreman JE, Eveleth DD, Powers JC. (1996) Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J. Med. Chem., 39 (20): 4089-98. [PMID:8831774]

2. Ovat A, Li ZZ, Hampton CY, Asress SA, Fernández FM, Glass JD, Powers JC. (2010) Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J. Med. Chem., 53 (17): 6326-36. [PMID:20690647]

How to cite this page

C2: Calpain: calpain 2. Last modified on 29/01/2016. Accessed on 28/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,