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cathepsin F

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Target not currently curated in GtoImmuPdb

Target id: 2347

Nomenclature: cathepsin F

Family: C1: Papain

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 484 11q13.2 CTSF cathepsin F
Mouse - 462 19 A Ctsf cathepsin F
Rat - 462 1q43 Ctsf cathepsin F
Previous and Unofficial Names Click here for help
CATSF | CLN13
Database Links Click here for help
Specialist databases
MEROPS C01.018 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.41

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
VBY-825 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.3 pKi 1
pKi 8.3 (Ki 4.7x10-9 M) [1]
compound (R)-26 [PMID: 22686657] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 2.1x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Ceroid lipofuscinosis, neuronal, 13
Synonyms: CLN13 disease [Orphanet: ORPHA352709]
Neuronal ceroid lipofuscinosis [Disease Ontology: DOID:14503]
Disease Ontology: DOID:14503
OMIM: 615362
Orphanet: ORPHA352709

References

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1. Elie BT, Gocheva V, Shree T, Dalrymple SA, Holsinger LJ, Joyce JA. (2010) Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie, 92 (11): 1618-24. [PMID:20447439]

2. Frizler M, Schmitz J, Schulz-Fincke AC, Gütschow M. (2012) Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem, 55 (12): 5982-6. [PMID:22686657]

How to cite this page

C1: Papain: cathepsin F. Last modified on 20/04/2020. Accessed on 18/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2347.