Top ▲

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

insulin degrading enzyme

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2371

Nomenclature: insulin degrading enzyme

Family: M16: Pitrilysin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1019 10q23.33 IDE insulin degrading enzyme
Mouse - 1019 19 32.24 cM Ide insulin degrading enzyme
Rat - 1019 1q53 Ide insulin degrading enzyme
Previous and Unofficial Names Click here for help
INSDEGM | insulin protease | insulinase | insulysin
Database Links Click here for help
Specialist databases
MEROPS M16.982 (Hs)
Other databases
Alphafold P14735 (Hs), Q9JHR7 (Mm), P35559 (Rn)
BRENDA 3.4.24.56
ChEMBL Target CHEMBL1293287 (Hs), CHEMBL3232680 (Mm)
DrugBank Target P14735 (Hs)
Ensembl Gene ENSG00000119912 (Hs), ENSMUSG00000056999 (Mm), ENSRNOG00000016833 (Rn)
Entrez Gene 3416 (Hs), 15925 (Mm), 25700 (Rn)
Human Protein Atlas ENSG00000119912 (Hs)
KEGG Enzyme 3.4.24.56
KEGG Gene hsa:3416 (Hs), mmu:15925 (Mm), rno:25700 (Rn)
OMIM 146680 (Hs)
Pharos P14735 (Hs)
RefSeq Nucleotide NM_001165946 (Hs), NM_004969 (Hs), NM_031156 (Mm), NM_013159 (Rn)
RefSeq Protein NP_004960 (Hs), NP_001159418 (Hs), NP_112419 (Mm), NP_037291 (Rn)
SynPHARM 82443 (in complex with NTE-1)
82444 (in complex with NTE-2)
82445 (in complex with quinoline 2)
UniProtKB P14735 (Hs), Q9JHR7 (Mm), P35559 (Rn)
Wikipedia IDE (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of insulin degrading enzyme complexed with inhibitor NTE-1.
PDB Id:  4PF9
Ligand:  NTE-1
Resolution:  2.5Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of insulin degrading enzyme complexed with inhibitor quinoline 2.
PDB Id:  4PF7
Ligand:  quinoline 2
Resolution:  2.33Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of insulin degrading enzyme complexed with inhibitor NTE-2
PDB Id:  4PFC
Ligand:  NTE-2
Resolution:  2.21Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 3.4.24.56

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
NTE-1 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 8.4 pIC50 1
⤷ pIC50 8.4 (IC50 4x10-9 M) [1]
NTE-2 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 7.7 pIC50 1
⤷ pIC50 7.7 (IC50 1.8x10-8 M) [1]
quinoline 2 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 5.7 pIC50 1
⤷ pIC50 5.7 (IC50 2x10-6 M) [1]

References

Show »

1. Durham TB, Toth JL, Klimkowski VJ, Cao JX, Siesky AM, Alexander-Chacko J, Wu GY, Dixon JT, McGee JE, Wang Y et al.. (2015) Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem, 290 (33): 20044-59. [PMID:26085101]

How to cite this page

M16: Pitrilysin: insulin degrading enzyme. Last modified on 30/03/2016. Accessed on 29/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2371.