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legumain

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Target not currently curated in GtoImmuPdb

Target id: 2380

Nomenclature: legumain

Family: C13: Legumain

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 433 14q32.12 LGMN legumain
Mouse - 435 12 E Lgmn legumain
Rat - 435 6q32 Lgmn legumain
Previous and Unofficial Names Click here for help
AEP1 | asparagine endo peptidase | asparagine endopeptidase | asparaginyl endopeptidase 1 | LGMN1 | protease, cysteine 1 | Prsc1
Database Links Click here for help
Specialist databases
MEROPS C13.004 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.34

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7u [PMID: 24775305] Small molecule or natural product Primary target of this compound Hs Inhibition 9.1 pIC50 1
pIC50 9.1 (IC50 9x10-10 M) [1]
compound 18 [PMID: 38090813] Small molecule or natural product Hs Inhibition 8.1 pIC50 2
pIC50 8.1 (IC50 7.8x10-9 M) [2]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  Cellular signalling
Immuno Process:  Immune regulation
Immuno Process:  Chemotaxis & migration

References

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1. Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P et al.. (2014) P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett, 24 (11): 2521-4. [PMID:24775305]

2. Krummenacher D, He W, Kuhn B, Schnider C, Beurier A, Brom V, Sivasothy T, Marty C, Tosstorff A, Hewings DS et al.. (2023) Discovery of Orally Available and Brain Penetrant AEP Inhibitors. J Med Chem, 66 (24): 17026-17043. [PMID:38090813]

How to cite this page

C13: Legumain: legumain. Last modified on 22/01/2024. Accessed on 20/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2380.