legumain | C13: Legumain | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 2380

Nomenclature: legumain

Family: C13: Legumain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 433 14q32.12 LGMN legumain
Mouse - 435 12 E Lgmn legumain
Rat - 435 6q32 Lgmn legumain
Previous and Unofficial Names
AEP1 | LGMN1 | protease, cysteine 1 | Prsc1 | asparaginyl endopeptidase 1
Database Links
Specialist databases
MEROPS C13.004 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7u [PMID: 24775305] Hs Inhibition 9.1 pIC50 1
pIC50 9.1 (IC50 9x10-10 M) [1]


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1. Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P et al.. (2014) P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg. Med. Chem. Lett., 24 (11): 2521-4. [PMID:24775305]

How to cite this page

C13: Legumain: legumain. Last modified on 23/07/2015. Accessed on 18/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2380.