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proprotein convertase subtilisin/kexin type 5

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Target not currently curated in GtoImmuPdb

Target id: 2385

Nomenclature: proprotein convertase subtilisin/kexin type 5

Family: S8: Subtilisin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1860 9q21.13 PCSK5 proprotein convertase subtilisin/kexin type 5
Mouse 1 1877 19 12.86 cM Pcsk5 proprotein convertase subtilisin/kexin type 5
Rat 1 1809 1q51 Pcsk5 proprotein convertase subtilisin/kexin type 5
Previous and Unofficial Names Click here for help
PC5A | PC6 | PC5/6A | proprotein convertase 5 | proprotein convertase 6 | SPC6
Database Links Click here for help
Specialist databases
MEROPS S08.076 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.6x10-9 M) [1]
furin inhibitor peptide Peptide Click here for species-specific activity table Hs Inhibition 6.6 pKi 2
pKi 6.6 (Ki 2.32x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem, 53 (3): 1067-75. [PMID:20038105]

2. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem, 282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 5. Last modified on 28/07/2015. Accessed on 14/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,