progastricsin | A1: Pepsin | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 2391

Nomenclature: progastricsin

Family: A1: Pepsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 388 6p21.1 PGC progastricsin
Mouse - 392 17 C Pgc progastricsin (pepsinogen C)
Rat - 392 9q12 Pgc progastricsin
Previous and Unofficial Names
gastricsin | PG1 | Upg1 | urinary pepsinogen 1 | progastricsin (pepsinogen C)
Database Links
Specialist databases
MEROPS A01.003 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 8410973] Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 9x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002803 positive regulation of antibacterial peptide production IMP


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1. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J. Med. Chem., 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: progastricsin. Last modified on 23/07/2015. Accessed on 07/06/2020. IUPHAR/BPS Guide to PHARMACOLOGY,