progastricsin | A1: Pepsin | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

progastricsin

Target not currently curated in GtoImmuPdb

Target id: 2391

Nomenclature: progastricsin

Family: A1: Pepsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 388 6p21.1 PGC progastricsin
Mouse - 392 17 C Pgc progastricsin (pepsinogen C)
Rat - 392 9q12 Pgc progastricsin
Previous and Unofficial Names
gastricsin | PG1 | Upg1 | urinary pepsinogen 1 | progastricsin (pepsinogen C)
Database Links
Specialist databases
MEROPS A01.003 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.23.3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 8410973] Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 9x10-10 M) [1]

References

Show »

1. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J. Med. Chem., 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: progastricsin. Last modified on 23/07/2015. Accessed on 13/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2391.