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proteasome 20S subunit beta 1

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Target not currently curated in GtoImmuPdb

Target id: 2404

Nomenclature: proteasome 20S subunit beta 1

Family: T1: Proteasome

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 241 6q27 PSMB1 proteasome 20S subunit beta 1
Mouse - 240 17 8.95 cM Psmb1 proteasome (prosome, macropain) subunit, beta type 1
Rat - 240 1q12 Psmb1 proteasome 20S subunit beta 1
Previous and Unofficial Names Click here for help
component C5 of proteasome | HC5 | Lmpc5 | macropain subunit C5 | PMSB1 | proteasome gamma chain | proteasome subunit C5 | multicatalytic endopeptidase complex subunit C5 | proteasome (prosome, macropain) subunit, beta type 1 | proteasome (prosome, macropain) subunit, beta type, 1 | proteasome (prosome | proteasome subunit beta 1
Database Links Click here for help
Specialist databases
MEROPS T01.986 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.25.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3b [PMID: 24946214] Small molecule or natural product Hs Inhibition 6.6 pKi 1
pKi 6.6 (Ki 2.4x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0070498 interleukin-1-mediated signaling pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0050852 T cell receptor signaling pathway TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 5 GO processes
GO:0000209 protein polyubiquitination TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043312 neutrophil degranulation TAS
GO:0050852 T cell receptor signaling pathway TAS

References

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1. Troiano V, Scarbaci K, Ettari R, Micale N, Cerchia C, Pinto A, Schirmeister T, Novellino E, Grasso S, Lavecchia A et al.. (2014) Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. Eur J Med Chem, 83: 1-14. [PMID:24946214]

How to cite this page

T1: Proteasome: proteasome 20S subunit beta 1. Last modified on 12/09/2019. Accessed on 18/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2404.