Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	241	6q27	PSMB1	proteasome 20S subunit beta 1
Mouse	-	240	17 8.95 cM	Psmb1	proteasome (prosome, macropain) subunit, beta type 1
Rat	-	240	1q12	Psmb1	proteasome 20S subunit beta 1

Previous and Unofficial Names

component C5 of proteasome | HC5 | Lmpc5 | macropain subunit C5 | PMSB1 | proteasome gamma chain | proteasome subunit C5 | multicatalytic endopeptidase complex subunit C5 | proteasome (prosome, macropain) subunit, beta type 1 | proteasome (prosome, macropain) subunit, beta type, 1 | proteasome (prosome | proteasome subunit beta 1

Database Links
Specialist databases
MEROPS	T01.986 (Hs)
Other databases
Alphafold	P20618 (Hs), O09061 (Mm), P18421 (Rn)
BRENDA	3.4.25.1
CATH/Gene3D	3.60.20.10
ChEMBL Target	CHEMBL4208 (Hs), CHEMBL4523121 (Mm)
DrugBank Target	P20618 (Hs)
Ensembl Gene	ENSG00000008018 (Hs), ENSMUSG00000014769 (Mm), ENSRNOG00000001488 (Rn)
Entrez Gene	5689 (Hs), 19170 (Mm), 94198 (Rn)
Human Protein Atlas	ENSG00000008018 (Hs)
KEGG Enzyme	3.4.25.1
KEGG Gene	hsa:5689 (Hs), mmu:19170 (Mm), rno:94198 (Rn)
OMIM	602017 (Hs)
Pharos	P20618 (Hs)
RefSeq Nucleotide	NM_002793 (Hs), NM_011185 (Mm), NM_053590 (Rn)
RefSeq Protein	NP_002784 (Hs), NP_035315 (Mm), NP_446042 (Rn)
UniProtKB	P20618 (Hs), O09061 (Mm), P18421 (Rn)
Wikipedia	PSMB1 (Hs)

Enzyme Reaction
EC Number: 3.4.25.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 3b [PMID: 24946214] Hs Inhibition 6.6 pKi 1 ⤷ pKi 6.6 (Ki 2.4x10-7 M) [1]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Antigen presentation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cellular signalling