glutaminyl-peptide cyclotransferase | M28: Aminopeptidase Y | IUPHAR/BPS Guide to PHARMACOLOGY

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glutaminyl-peptide cyclotransferase

Target not currently curated in GtoImmuPdb

Target id: 2411

Nomenclature: glutaminyl-peptide cyclotransferase

Family: M28: Aminopeptidase Y

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 361 2p22 QPCT glutaminyl-peptide cyclotransferase
Mouse - 362 17 E3 Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
Rat - 313 6q11 Qpct glutaminyl-peptide cyclotransferase
Previous and Unofficial Names
GCT | glutaminyl cyclase | glutaminyl-tRNA cyclotransferase | QC
Database Links
Specialist databases
MEROPS M28.974 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PBD150 Hs Inhibition 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS


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1. Buchholz M, Heiser U, Schilling S, Niestroj AJ, Zunkel K, Demuth HU. (2006) The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J. Med. Chem., 49 (2): 664-77. [PMID:16420052]

How to cite this page

M28: Aminopeptidase Y: glutaminyl-peptide cyclotransferase. Last modified on 23/06/2015. Accessed on 12/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY,