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Target not currently curated in GtoImmuPdb
Target id: 2436
Nomenclature: acetyl-CoA acetyltransferase 2
Family: Lanosterol biosynthesis pathway
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 397 | 6q25.3 | ACAT2 | acetyl-CoA acetyltransferase 2 | 2 |
| Mouse | - | 397 | 17 8.73 cM | Acat2 | acetyl-Coenzyme A acetyltransferase 2 | |
| Rat | - | 397 | 1q11 | Acat2 | acetyl-CoA acetyltransferase 2 | |
| Previous and Unofficial Names |
| Acat3 | Acetyl-CoA acetyltransferase, cytosolic | Cytosolic acetoacetyl-CoA thiolase | acetoacetyl Coenzyme A thiolase | acetyl-Coenzyme A acetyltransferase 3 |
| Database Links |
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| Alphafold | Q9BWD1 (Hs), Q8CAY6 (Mm), Q5XI22 (Rn) |
| BRENDA | 2.3.1.9 |
| CATH/Gene3D | 3.40.47.10 |
| Ensembl Gene | ENSG00000120437 (Hs), ENSMUSG00000023832 (Mm), ENSRNOG00000019189 (Rn) |
| Entrez Gene | 39 (Hs), 110460 (Mm), 308100 (Rn) |
| Human Protein Atlas | ENSG00000120437 (Hs) |
| KEGG Enzyme | 2.3.1.9 |
| KEGG Gene | hsa:39 (Hs), mmu:110460 (Mm), rno:308100 (Rn) |
| OMIM | 100678 (Hs) |
| Pharos | Q9BWD1 (Hs) |
| RefSeq Nucleotide | NM_005891 (Hs), NM_009338 (Mm), NM_001006995 (Rn) |
| RefSeq Protein | NP_005882 (Hs), NP_033364 (Mm), NP_001006996 (Rn) |
| UniProtKB | Q9BWD1 (Hs), Q8CAY6 (Mm), Q5XI22 (Rn) |
| Wikipedia | ACAT2 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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1. Ikenoya M, Yoshinaka Y, Kobayashi H, Kawamine K, Shibuya K, Sato F, Sawanobori K, Watanabe T, Miyazaki A. (2007) A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis, 191 (2): 290-7. [PMID:16820149]
2. Masuno M, Fukao T, Song XQ, Yamaguchi S, Orii T, Kondo N, Imaizumi K, Kuroki Y. (1996) Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. Genomics, 36 (1): 217-8. [PMID:8812443]
