integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Integrins | IUPHAR/BPS Guide to PHARMACOLOGY

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integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Target not currently curated in GtoImmuPdb

Target id: 2455

Nomenclature: integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Family: Integrins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
integrin α1β1
integrin α2β1
integrin α4β1
integrin α5β1
integrin α6β1
integrin α10β1
integrin α11β1
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 798 10p11.2 ITGB1 integrin subunit beta 1
Mouse - 798 8 E2 Itgb1 integrin beta 1 (fibronectin receptor beta)
Rat - 799 19q12 Itgb1 integrin subunit beta 1
Previous and Unofficial Names
beta1 integrin | CD antigen CD29 | Fibronectin receptor subunit beta | FNRB | Glycoprotein IIa | GPIIA | MDF2 | MSK12 | VLA-4 subunit beta | integrin, beta 1
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7 [PMID: 31381331] Hs Inhibition 7.7 pKi 1
pKi 7.7 (Ki 2x10-8 M) [1]
Description: Ki estimated from the binding affinity of the test compound to αvβ6 integrin in a radioligand binding assay.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006909 phagocytosis ISS
GO:0050900 leukocyte migration TAS
GO:0050901 leukocyte tethering or rolling IMP
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0031623 receptor internalization ISS
GO:0045807 positive regulation of endocytosis ISO
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050776 regulation of immune response TAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0007159 leukocyte cell-cell adhesion IDA
GO:0050900 leukocyte migration TAS
GO:0050901 leukocyte tethering or rolling IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001618 virus receptor activity IEA

References

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1. Barrett TN, Taylor JA, Barker D, Procopiou PA, Thompson JDF, Barrett J, Le J, Lynn SM, Pogany P, Pratley C et al.. (2019) Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation. J. Med. Chem., 62 (16): 7543-7556. [PMID:31381331]

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