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alkaline ceramidase 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2468

Nomenclature: alkaline ceramidase 1

Family: Alkaline ceramidases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 264 19p13.3 ACER1 alkaline ceramidase 1
Mouse 7 273 17 D Acer1 alkaline ceramidase 1
Rat - 273 9q11 Acer1 alkaline ceramidase 1
Previous and Unofficial Names Click here for help
Acylsphingosine deacylase 3 | Alkaline CDase 1 | AlkCDase 1 | ASAH3 | Cer1
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: ceramide -> sphingosine + a fatty acid
Immunopharmacology Comments
The major biological role of ACER1 is that of maintaining skin homeostasis via regulation of keratinocyte differentiation [1]. ACER1 is included in GtoImmuPdb because of its involvement in generating the sphingolipid sphingosine, which is subsequently phosphorylated (by sphingosine kinase) to the bioactive lipid mediator S1P [3]. S1P is a major regulator of the vascular and immune systems. In the immune system S1P activation of its receptor S1P1R promotes trafficking of T and B cells from the lymphoid organs into the lymphatic vessels.
Tissue Distribution Click here for help
Human epidermal keratinocytes
Species:  Human
Technique:  In situ hybridization, RT-PCR.
References:  2


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1. Coant N, Sakamoto W, Mao C, Hannun YA. (2017) Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul, 63: 122-131. [PMID:27771292]

2. Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y. (2006) Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res, 47 (5): 1063-70. [PMID:16477081]

3. Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM. (2003) Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem, 278 (33): 31184-91. [PMID:12783875]

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