UDP-glucose ceramide glucosyltransferase | Ceramide glucosyltransferase | IUPHAR/BPS Guide to PHARMACOLOGY

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UDP-glucose ceramide glucosyltransferase

Target not currently curated in GtoImmuPdb

Target id: 2528

Nomenclature: UDP-glucose ceramide glucosyltransferase

Family: Ceramide glucosyltransferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 394 9q31 UGCG UDP-glucose ceramide glucosyltransferase
Mouse - 394 4 B3 Ugcg UDP-glucose ceramide glucosyltransferase
Rat - 394 5q24 Ugcg UDP-glucose ceramide glucosyltransferase
Previous and Unofficial Names
Epcs21 | GCS | GLCT-1 | Glucosylceramide synthase | Ugcgl
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: UDP-glucose + ceramide = uridine diphosphate + glucosylceramide

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
miglustat Hs Inhibition 5.1 pKi 1
pKi 5.1 (Ki 7.4x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033210 leptin-mediated signaling pathway ISS


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1. Butters TD, van den Broek LAGM, Fleet GWJ, Krulle TM, Wormald MR, Dwek RA, Platt FM. (2000) Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis. Tetrahedron: Assymetry, 11 (1): 113-124.

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