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UDP-glucose ceramide glucosyltransferase

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Target not currently curated in GtoImmuPdb

Target id: 2528

Nomenclature: UDP-glucose ceramide glucosyltransferase

Family: Ceramide glucosyltransferase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 5 394 9q31.3 UGCG UDP-glucose ceramide glucosyltransferase
Mouse 5 394 4 B3 Ugcg UDP-glucose ceramide glucosyltransferase
Rat 5 394 5q24 Ugcg UDP-glucose ceramide glucosyltransferase
Previous and Unofficial Names Click here for help
Epcs21 | GCS | GLCT-1 | Glucosylceramide synthase | Ugcgl
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: UDP-glucose + ceramide = UDP + glucosylceramide

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
miglustat Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition 5.1 pKi 2
pKi 5.1 (Ki 7.4x10-6 M) [2]
T-690 Small molecule or natural product Hs Inhibition 7.8 pIC50 3
pIC50 7.8 (IC50 1.5x10-8 M) [3]
venglustat Small molecule or natural product Ligand has a PDB structure Hs Inhibition >5.3 pIC50 1
pIC50 >5.3 (IC50 <5x10-6 M) [1]
Description: Inhibition of glucosylceramide synthase activity in microsomes derived from human A375 melanoma cells, using fluorescent ceramide as substrate.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
General Comments
UDP-glucose ceramide glucosyltransferase (a.k.a. glucosylceramide synthase) is a key enzyme in glycolipid synthesis and it is a therapeutic target for the lysosomal storage disorder Gaucher's disease (GD). Inhibitors of this enzyme are predicted to reduce accumulation of glycosphingolipids (e.g. glucosylsphingosine) that are associated with disease pathologies.


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1. Bourque E, Celatka C, Hirth B, Metz M, Zhao Z, Skerlj R, Xiang Y, Jancisics K, Marshall J, Cheng S et al.. (2014) Glucosylceramide synthase inhibitors. Patent number: WO2012129084A2. Assignee: Genzyme Corporation. Priority date: 18/03/2011. Publication date: 24/04/2014.

2. Butters TD, van den Broek LAGM, Fleet GWJ, Krulle TM, Wormald MR, Dwek RA, Platt FM. (2000) Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis. Tetrahedron: Assymetry, 11 (1): 113-124.

3. Tanaka Y, Seto M, Kakegawa K, Takami K, Kikuchi F, Yamamoto T, Nakamura M, Daini M, Murakami M, Ohashi T et al.. (2022) Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem, 65 (5): 4270-4290. [PMID:35188773]

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