<i>GPRC5B</i> | Class C Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 259

Nomenclature: GPRC5B

Family: Class C Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 395 16p12 GPRC5B G protein-coupled receptor class C group 5 member B 1,4
Mouse 7 410 7 F3 Gprc5b G protein-coupled receptor, family C, group 5, member B 3
Rat 7 394 1q35 Gprc5b G protein-coupled receptor, class C, group 5, member B
Previous and Unofficial Names
RAIG2 | retinoic acid-induced gene 2 protein | G protein-coupled receptor, class C, group 5, member B | G protein-coupled receptor
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
High expression in adult kidney, pancreas and testis.
Medium expression in adult brain, heart, prostate, small intestine and spleen.
Low expression in adult liver, placenta, skeletal muscle, colon, ovary and thymus.
Not detectable in adult lung and peripheral leukocyte.
Species:  Human
Technique:  RT-PCR
References:  2
High expression in adult brain and spinal cord.
Medium to low expression in adult pancreas, testis, uterus and stomach.
Species:  Human
Technique:  RT-PCR
References:  4
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Orphan receptor.
mRNA expression is induced by retinoic acid in some cell lines.


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1. Bräuner-Osborne H, Krogsgaard-Larsen P. (2000) Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics, 65 (2): 121-8. [PMID:10783259]

2. Cheng Y, Lotan R. (1998) Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J Biol Chem., 273: 35008-35015. [PMID:9446598]

3. Inoue S, Sano H, Ohta M. (2000) Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem. Biophys. Res. Commun., 268: 553-561. [PMID:10679242]

4. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. (2000) Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics, 67 (1): 8-18. [PMID:10945465]


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