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Target not currently curated in GtoImmuPdb
Target id: 2590
Nomenclature: pancreatic lipase
Abbreviated Name: PNLIP
Family: Hydrolases & Lipases
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 465 | 10q25.3 | PNLIP | pancreatic lipase | |
Mouse | - | 465 | 19 54.46 cM | Pnlip | pancreatic lipase | |
Rat | - | 465 | 1q55 | Pnlip | pancreatic lipase |
Previous and Unofficial Names |
pancreatic triacylglycerol lipase | pancreatic triglyceride lipase | PANLI | PL |
Database Links | |
Alphafold | P16233 (Hs), Q6P8U6 (Mm), P27657 (Rn) |
BRENDA | 3.1.1.3 |
CATH/Gene3D | 2.60.60.20, 3.40.50.1820 |
ChEMBL Target | CHEMBL1812 (Hs) |
DrugBank Target | P16233 (Hs) |
Ensembl Gene | ENSG00000175535 (Hs), ENSMUSG00000046008 (Mm), ENSRNOG00000017725 (Rn) |
Entrez Gene | 5406 (Hs), 69060 (Mm), 25702 (Rn) |
Human Protein Atlas | ENSG00000175535 (Hs) |
KEGG Enzyme | 3.1.1.3 |
KEGG Gene | hsa:5406 (Hs), mmu:69060 (Mm), rno:25702 (Rn) |
OMIM | 246600 (Hs) |
Pharos | P16233 (Hs) |
RefSeq Nucleotide | NM_000936 (Hs), NM_026925 (Mm), NM_013161 (Rn) |
RefSeq Protein | NP_000927 (Hs), NP_081201 (Mm), NP_037293 (Rn) |
UniProtKB | P16233 (Hs), Q6P8U6 (Mm), P27657 (Rn) |
Wikipedia | PNLIP (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific inhibitor tables |
1. Bustanji Y, Issa A, Mohammed M, Hudaib M, Tawah, K, Alkhatib H, Almarsi I, Al-Khalidi B. (2010) Inhibition of hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituents. Journal of Medicinal Plants Research, 4 (21): 2235-2242.
2. Yamada Y, Kato T, Ogino H, Ashina S, Kato K. (2008) Cetilistat (ATL-962), a Novel Pancreatic Lipase Inhibitor, Ameliorates Body Weight Gain and Improves Lipid Profiles in Rats. Horm Metab Res, 40 (8): 539-543. DOI: 10.1055/s-2008-1076699