lipase G, endothelial type | Hydrolases | IUPHAR/BPS Guide to PHARMACOLOGY

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lipase G, endothelial type

Target not currently curated in GtoImmuPdb

Target id: 2591

Nomenclature: lipase G, endothelial type

Abbreviated Name: LIPG

Family: Hydrolases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 500 18q21.1 LIPG lipase G, endothelial type
Mouse - 500 18 E2 Lipg lipase, endothelial
Rat - 493 18q12.3 Lipg lipase G, endothelial type
Previous and Unofficial Names
EDL | EL | endothelial cell-derived lipase|lipase G | lipase, endothelial | lipase
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GSK-264220A Hs Irreversible inhibition 8.9 pIC50 1
pIC50 8.9 (IC50 1.3x10-7 M) [1]

References

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1. Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA et al.. (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg. Med. Chem. Lett., 19 (1): 27-30. [PMID:19058966]

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