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hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

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Target not currently curated in GtoImmuPdb

Target id: 2622

Nomenclature: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Family: 1.-.-.- Oxidoreductases, 5.-.-.- Isomerases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 372 1p12 HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Mouse 1 373 3 42.89 cM Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Rat - 373 2q34 Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Previous and Unofficial Names Click here for help
3 beta-hydroxysteroid dehydrogenase/Delta 5 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | hydroxy-delta-5-steroid dehydrogenase
Database Links Click here for help
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.1.1.145
EC Number: 5.3.3.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
trilostane Small molecule or natural product Approved drug Primary target of this compound N/A Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4x10-9 M) Note that the species is not specified in the referenced article. [1]
Description: In vitro enzyme inhibition
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase type II deficiency
Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255]
Disease Ontology: DOID:12255
OMIM: 201810
Orphanet: ORPHA90791

References

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1. Rabe T, Kiesel L, Kellermann J, Weidenhammer K, Runnebaum B, Potts GO. (1983) Inhibition of human placental progesterone synthesis and aromatase activity by synthetic steroidogenic inhibitors in vitro. Fertil. Steril., 39 (6): 829-35. [PMID:6574022]

How to cite this page

5.-.-.- Isomerases: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2. Last modified on 13/08/2015. Accessed on 25/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2622.