Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	445	20q13.33	HRH3	histamine receptor H3	16,37
Mouse	7	445	2 102.62 cM	Hrh3	histamine receptor H3	13,50
Rat	7	445	3q43	Hrh3	histamine receptor H3	36

Previous and Unofficial Names

GPCR97 | H3R | HH3R

Database Links
Specialist databases
GPCRdb	hrh3_human (Hs), hrh3_mouse (Mm), hrh3_rat (Rn)
Other databases
Alphafold	Q9Y5N1 (Hs), P58406 (Mm), Q9QYN8 (Rn)
ChEMBL Target	CHEMBL264 (Hs), CHEMBL3263 (Mm), CHEMBL4124 (Rn)
DrugBank Target	Q9Y5N1 (Hs)
Ensembl Gene	ENSG00000101180 (Hs), ENSMUSG00000039059 (Mm), ENSRNOG00000061153 (Rn)
Entrez Gene	11255 (Hs), 99296 (Mm), 85268 (Rn)
Human Protein Atlas	ENSG00000101180 (Hs)
KEGG Gene	hsa:11255 (Hs), mmu:99296 (Mm), rno:85268 (Rn)
OMIM	604525 (Hs)
Pharos	Q9Y5N1 (Hs)
RefSeq Nucleotide	NM_007232 (Hs), NM_133849 (Mm), NM_053506 (Rn)
RefSeq Protein	NP_009163 (Hs), NP_598610 (Mm), NP_445958 (Rn)
UniProtKB	Q9Y5N1 (Hs), P58406 (Mm), Q9QYN8 (Rn)
Wikipedia	HRH3 (Hs)

Natural/Endogenous Ligands
histamine

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference [3H](R)-α-methylhistamine Hs Full agonist 9.2 pKd 35 ⤷ pKd 9.2 (Kd 6x10-10 M) [35] N-[3H]methylhistamine Hs Full agonist 9.1 pKd 35 ⤷ pKd 9.1 [35] N-[3H]methylhistamine Rn Full agonist 9.1 pKd 36 ⤷ pKd 9.1 [36] N-[3H]α-methylhistamine Mm Full agonist 9.0 pKd 13 ⤷ pKd 9.0 (Kd 1x10-9 M) [13] [3H]histamine Hs Full agonist 8.0 pKd 35,43 ⤷ pKd 8.0 [35,43] iodoproxyfan Hs Full agonist 10.0 pKi 58 ⤷ pKi 10.0 [58] immepip Mm Full agonist 9.8 pKi 13 ⤷ pKi 9.8 [13] GSK-189254 Hs Inverse agonist 9.7 pKi 39 ⤷ pKi 9.7 (Ki 2x10-10 M) [39] iodoproxyfan Rn Full agonist 9.6 pKi 58 ⤷ pKi 9.6 [58] cipralisant Rn Full agonist 9.5 pKi 58 ⤷ pKi 9.5 [58] imetit Rn Full agonist 9.0 – 9.7 pKi 36,41,58 ⤷ pKi 9.0 – 9.7 [36,41,58] imetit Hs Full agonist 8.8 – 9.7 pKi 16,35-36,57-58 ⤷ pKi 8.8 – 9.7 [16,35-36,57-58] imetit Mm Full agonist 8.8 – 9.7 pKi 13,50 ⤷ pKi 8.8 – 9.7 [13,50] immepip Hs Full agonist 8.8 – 9.7 pKi 16,31,35-36,58 ⤷ pKi 8.8 – 9.7 [16,31,35-36,58] immethridine Hs Full agonist 9.1 pKi 30 ⤷ pKi 9.1 [30] N-α-methylhistamine Mm Full agonist 9.0 pKi 13 ⤷ pKi 9.0 [13] methimepip Hs Full agonist 9.0 pKi 29 ⤷ pKi 9.0 (Ki 1x10-9 M) [29] N-methylhistamine Hs Full agonist 8.6 – 9.3 pKi 16,35-36 ⤷ pKi 8.6 – 9.3 [16,35-36] immepip Rn Full agonist 8.8 – 8.9 pKi 36,58 ⤷ pKi 8.8 – 8.9 [36,58] N-methylhistamine Rn Full agonist 8.8 pKi 36 ⤷ pKi 8.8 [36] (R)-α-methylhistamine Hs Full agonist 8.4 – 9.2 pKi 16,33,35-36,57-58 ⤷ pKi 8.4 – 9.2 [16,33,35-36,57-58] MK-0249 Hs Inverse agonist 8.8 pKi 42 ⤷ pKi 8.8 (Ki 1.7x10-9 M) [42] GR 175737 Hs Partial agonist 8.6 pKi 58 ⤷ pKi 8.6 [58] cipralisant Hs Full agonist 8.6 pKi 58 ⤷ pKi 8.6 [58] VUF 8328 Hs Partial agonist 8.5 pKi 57 ⤷ pKi 8.5 [57] (R)-α-methylhistamine Mm Full agonist 8.4 pKi 13 ⤷ pKi 8.4 [13] imbutamine Hs Full agonist 8.4 pKi 31 ⤷ pKi 8.4 [31] compound 3a [PMID: 18606542] Hs Inverse agonist 8.4 pKi 49 ⤷ pKi 8.4 (Ki 4x10-9 M) [49] Description: Affinity measured in a saturation binding experiment using human H3 receptor-expressing CHO cells, and [3H]-(R)-α-methylhistamine as tracer. (R)-α-methylhistamine Rn Full agonist 8.0 – 8.7 pKi 33,36,58 ⤷ pKi 8.0 – 8.7 [33,36,58] proxyfan Mm Full agonist 8.2 – 8.5 pKi 50 ⤷ pKi 8.2 – 8.5 [50] GR 175737 Rn Partial agonist 8.3 pKi 58 ⤷ pKi 8.3 [58] impentamine Hs Full agonist 8.3 pKi 31 ⤷ pKi 8.3 [31] proxyfan Hs Full agonist 8.3 pKi 58 ⤷ pKi 8.3 [58] proxyfan Rn Full agonist 8.0 – 8.5 pKi 41,58 ⤷ pKi 8.0 – 8.5 [41,58] SUVN-G3031 Hs Inverse agonist 8.1 pKi 44 ⤷ pKi 8.1 (Ki 8.73x10-9 M) [44] histamine Hs Full agonist 7.8 – 8.3 pKi 16,31,33,35-36,58 ⤷ pKi 7.8 – 8.3 [16,31,33,35-36,58] VUF 5207 Hs Full agonist 7.8 pKi 57 ⤷ pKi 7.8 [57] (S)-α-methylhistamine Hs Full agonist 7.6 pKi 58 ⤷ pKi 7.6 [58] histamine Rn Full agonist 7.2 – 7.9 pKi 33,36,41 ⤷ pKi 7.2 – 7.9 [33,36,41] histamine Mm Full agonist 7.1 – 7.8 pKi 13,50 ⤷ pKi 7.1 – 7.8 [13,50] impromidine Hs Partial agonist 7.2 pKi 35 ⤷ pKi 7.2 [35] (S)-α-methylhistamine Rn Full agonist 6.6 pKi 58 ⤷ pKi 6.6 [58] ST-1006 Hs Agonist 6.3 pKi 45 ⤷ pKi 6.3 [45] dimaprit Hs Full agonist 6.1 pKi 35 ⤷ pKi 6.1 [35]
View species-specific agonist tables

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference [123I]iodoproxyfan Rn Antagonist 10.3 pKd 33 ⤷ pKd 10.3 [33] [123I]iodoproxyfan Hs Antagonist 10.2 pKd 33 ⤷ pKd 10.2 (Kd 6.3x10-11 M) [33] [125I]iodophenpropit Rn Antagonist 9.2 pKd 28 ⤷ pKd 9.2 (Kd 6x10-10 M) [28] GSK334429 Hs Antagonist 9.5 – 9.9 pKi 6,34 ⤷ pKi 9.5 – 9.9 (Ki 3.2x10-10 – 1.3x10-10 M) [6,34] clobenpropit Mm Antagonist 9.5 pKi 13 ⤷ pKi 9.5 [13] A-349821 Hs Inverse agonist 9.4 pKi 18 ⤷ pKi 9.4 [18] ABT-239 Hs Inverse agonist 9.4 pKi 19 ⤷ pKi 9.4 [19] clobenpropit Rn Antagonist 8.9 – 9.8 pKi 20,33,36,41,57-58 ⤷ pKi 8.9 – 9.8 [20,33,36,41,57-58] ciproxifan Mm Antagonist 9.1 – 9.4 pKi 50 ⤷ pKi 9.1 – 9.4 [50] A-317920 Rn Antagonist 9.2 pKi 18,20 ⤷ pKi 9.2 [18,20] JNJ-5207852 Hs Antagonist 9.2 pKi 1 ⤷ pKi 9.2 [1] iodophenpropit Rn Antagonist 8.8 – 9.1 pKi 57-58 ⤷ pKi 8.8 – 9.1 [57-58] clobenpropit Hs Antagonist 8.4 – 9.4 pKi 16,20,33,35-36,57-58 ⤷ pKi 8.4 – 9.4 (Ki 3.9x10-9 – 3.9x10-10 M) [16,20,33,35-36,57-58] ABT-239 Rn Inverse agonist 8.9 pKi 19 ⤷ pKi 8.9 [19] ciproxifan Rn Antagonist 8.4 – 9.3 pKi 18,20,33,41,58 ⤷ pKi 8.4 – 9.3 [18,20,33,41,58] A-349821 Rn Inverse agonist 8.8 pKi 18 ⤷ pKi 8.8 [18] enerisant Hs Inverse agonist 8.8 pKi 25 ⤷ pKi 8.8 (Ki 1.65x10-9 M) [25] Description: Determined using [3H]N-α-methylhistamine binding to the membranes of CHO-K1 cells expressing human recombinant H3 receptors. thioperamide Mm Antagonist 8.6 – 8.8 pKi 50 ⤷ pKi 8.6 – 8.8 [50] FUB 349 Hs Antagonist 8.7 pKi 33 ⤷ pKi 8.7 [33] PF-03654746 Hs Antagonist 8.6 pKi 56 ⤷ pKi 8.6 (Ki 2.3x10-9 M) [56] proxyfan Hs Antagonist 8.6 pKi 33 ⤷ pKi 8.6 [33] A-304121 Rn Antagonist 8.6 pKi 18,20 ⤷ pKi 8.6 [18,20] proxyfan Rn Antagonist 8.5 pKi 33 ⤷ pKi 8.5 [33] A331440 Hs Antagonist 8.5 pKi 23 ⤷ pKi 8.5 [23] iodophenpropit Hs Antagonist 8.2 – 8.7 pKi 57-58 ⤷ pKi 8.2 – 8.7 (Ki 6.31x10-9 – 1.99x10-9 M) [57-58] pitolisant Hs Antagonist 8.1 – 8.6 pKi 45,61 ⤷ pKi 8.1 – 8.6 (Ki 2.7x10-9 M) [45,61] Description: Measured in a [125I]iodoproxyfan binding assay in cells exogenously expressing the human H3 receptor. impentamine Hs Antagonist 8.3 pKi 57 ⤷ pKi 8.3 [57] impentamine Rn Antagonist 8.3 pKi 57 ⤷ pKi 8.3 [57] conessine Hs Antagonist 8.3 pKi 45 ⤷ pKi 8.3 [45] thioperamide Rn Antagonist 7.7 – 8.8 pKi 18,20,33,36,41,57-58 ⤷ pKi 7.7 – 8.8 [18,20,33,36,41,57-58] MK-0249 Hs Antagonist 8.2 pKi 45 ⤷ pKi 8.2 [45] enerisant Rn Inverse agonist 8.1 pKi 25 ⤷ pKi 8.1 (Ki 7.87x10-9 M) [25] FUB 349 Rn Antagonist 7.9 pKi 33 ⤷ pKi 7.9 [33] VUF 4904 Hs Antagonist 7.9 pKi 57 ⤷ pKi 7.9 [57] VUF14862 Hs Antagonist 7.7 pKi 24 ⤷ pKi 7.7 (Ki 1.95x10-8 M) [24] Description: Ki measured in the dark and compound in the trans configuration. FUB 349 Mm Antagonist 7.6 – 7.8 pKi 50 ⤷ pKi 7.6 – 7.8 [50] GT2394 Rn Antagonist 7.7 pKi 58 ⤷ pKi 7.7 [58] UCL-2138 Hs Antagonist 7.6 pKi 35 ⤷ pKi 7.6 [35] PF-03654746 Mm Antagonist 7.4 pKi 56 ⤷ pKi 7.4 (Ki 3.7x10-8 M) [56] thioperamide Hs Antagonist 7.1 – 7.7 pKi 16,18,20,33,36,57-58 ⤷ pKi 7.1 – 7.7 (Ki 7.94x10-8 – 1.99x10-8 M) Selective for H3/H4 compared to H1 and H3. [16,18,20,33,36,57-58] VUF14738 Hs Antagonist 7.3 pKi 24 ⤷ pKi 7.3 (Ki 4.786x10-8 M) [24] Description: Ki measured under UV illumination, and compound in cis configuration. burimamide Rn Antagonist 7.3 pKi 57 ⤷ pKi 7.3 [57] JB 98064 Hs Antagonist 7.3 pKi 58 ⤷ pKi 7.3 [58] burimamide Hs Antagonist 7.1 pKi 35,57 ⤷ pKi 7.1 [35,57] A-317920 Hs Antagonist 7.0 pKi 18,20 ⤷ pKi 7.0 [18,20] JB 98064 Rn Antagonist 7.0 pKi 58 ⤷ pKi 7.0 [58] ciproxifan Hs Antagonist 6.7 – 7.3 pKi 16,18,20,33,45,58 ⤷ pKi 6.7 – 7.3 [16,18,20,33,45,58] adriforant Hs Antagonist 6.7 pKi 45 ⤷ pKi 6.7 [45] FUB 465 Rn Antagonist 6.4 – 6.9 pKi 41 ⤷ pKi 6.4 – 6.9 [41] GT2394 Hs Antagonist 6.4 pKi 58 ⤷ pKi 6.4 [58] INCB-38579 Hs Antagonist 6.4 pKi 45 ⤷ pKi 6.4 [45] A-304121 Hs Antagonist 6.1 pKi 18,20 ⤷ pKi 6.1 [18,20] JNJ-39758979 Hs Antagonist 6.0 pKi 45 ⤷ pKi 6.0 (Ki 1x10-6 M) [45] clozapine Rn Antagonist 5.8 pKi 36 ⤷ pKi 5.8 [36]
View species-specific antagonist tables
Antagonist Comments
VUF 4904 is a neutral antagonist [57]. The affinity of VUF14738 decreases to 646 nM in the trans configuration adopted in the dark [24]. VUF14862 operates in the opposite direction, its affinity increases to 1.7 nM in the cis configuration adopted in the dark [24].

Immunopharmacology Comments

H3 receptor expression is low in peripheral tissues, but high in neuronal mast cells and eosinophils. It is not currently considered an important target in allergy.

Cell Type Associations

Immuno Cell Type:  Mast cells Cell Ontology Term:   mast cell (CL:0000097) Comment:  In humans, H3R expression is restricted to brain mast cells. References:  21

Immuno Cell Type:  Granulocytes Cell Ontology Term:   eosinophil (CL:0000771) Comment:  Eosinophils express all four histamine receptor subtypes. References:  22,40

Primary Transduction Mechanisms
Transducer	Effector/Response
Gi/Go family	Adenylyl cyclase inhibition
References:  14-15

Tissue Distribution
Brain: thalamus, caudate nucleus, putamen, cerebellum, amygdala, substantia nigra, hippocampus, hypothalamus, cerebral cortex. Species:  Human Technique:  Northern blotting and RT-PCR. References:  16
Brain: thalamus, hypothalamus, hippocampus > cerebellum, brainstem. Species:  Mouse Technique:  Radioligand binding. References:  27
Brain: cerebral cortex, basal ganglia, caudate putamen, nucleus accumbens, subthalamic nucleus, hypothalamus, thalamus, hippocampus, dentate gyrus, cerebellum. Species:  Mouse Technique:  in situ hybridisation. References:  50
Brain: cerebral cortex, hippocampus, cerebellum, striatum, olfactory tubercle, substantia nigra, thalamus. Species:  Mouse Technique:  Immunohistochemistry. References:  12
Brain: cerebral cortex, striatum, hypothalamus. Species:  Mouse Technique:  Southern blotting and RT-PCR. References:  50
Embryo: lipoblasts of adipose tissue, tongue. Adult: epithelial layer of the tongue, epithelial cells of hair follicles and epidermis, gastric mucosa of the stomach. Species:  Rat Technique:  in situ hybridisation. References:  26
Skin, dorsal root ganglia, superior cervical ganglia, spinal cord. Species:  Rat Technique:  Immunohistochemistry. References:  9
Brain: cerebral cortex, hippocampus, midbrain, hypothalamus, striatum, brainstem, cerebellum, olfactory tuberculum. Species:  Rat Technique:  Southern blotting and RT-PCR. References:  41
Brain: cerebral cortex, thalamic nuclei, hippocampus, dentate gyrus, basal ganglia, substantia nigra, caudate putamen, nucleus accumbens, amygdala, thalamus, hypothalamus, brainstem, cerebellum. Species:  Rat Technique:  in situ hybridisation. References:  47
Embryo: brain, spinal cord, spinal ganglia, tongue epithelium, salivary glands, respiratory epithelium, lung, stomach, intestine, skin, thymus, liver, adipose tissue. Adult: brain, spinal cord, spinal ganglia, tongue epithelium, stomach, intestine, skin, thymus. Species:  Rat Technique:  in situ hybridisation. References:  26
Cochlea. Species:  Rat Technique:  RT-PCR. References:  3
Embryo: adipose tissue, liver. Adult: brain. Species:  Rat Technique:  RT-PCR and Southern blotting. References:  26

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Functional Assays
Measurement of Ca2+ levels in HEK 293 cells transfected with the mouse H3 receptor. Species:  Mouse Tissue:  HEK 293 cells. Response measured:  Ca2+ mobilisation. References:  13
Measurement of Ca2+ levels in CHO cells transfected with the human H3 receptor. Species:  Human Tissue:  CHO cells. Response measured:  Ca2+ mobilisation. References:  16
Measurement of cAMP levels in SK-N-MC cells transfected with the rat H3 receptor. Species:  Rat Tissue:  SK-N-MC cells. Response measured:  Inhibition of cAMP accumulation. References:  36,57
Measurement of cAMP levels in SK-N-MC cells transfected with the human H3 receptor. Species:  Human Tissue:  SK-N-MC cells. Response measured:  Inhibition of cAMP accumulation. References:  57
Measurement of MAP kinase activation in COS-7 cells transfected with the rat H3 receptor. Species:  Rat Tissue:  COS-7 cells. Response measured:  Activation of p44/p42 MAPK. References:  17

Physiological Functions
Inhibition of substantia nigra pars reticulata (SNr) inhibitory projection neuron firing frequency (via cell hyperpolarisation). The balance between this effect and the opposing effect of H1 and H2 receptors may contribute to movement control. Species:  Mouse Tissue:  Coronal midbrain slices. References:  60
Inhibition of gastric acid secretion. Species:  Rat Tissue:  In vivo. References:  5
Inhibition of serotonin release in the substantia nigra pars reticulata (SNr). Species:  Rat Tissue:  Midbrain slices. References:  52
Inhibition of acetylcholine release. Species:  Rat Tissue:  Isolated stomach. References:  59
Inhibition of glutamate release. Species:  Rat Tissue:  Dentate gyrus. References:  7
Inhibition of cholinergic transmission. Role in consolidation of fear conditioning. Species:  Rat Tissue:  In vivo. References:  8,46
Vasoconstriction. Species:  Human Tissue:  Turbinate mucosa strips. References:  55
Regulation of food intake and body weight. Species:  Rat Tissue:  In vivo. References:  38
Activation of spinal H3 receptors inhibits mechanical nociception. Species:  Human Tissue:  In vivo. References:  11
Autoreceptor: inhibition of histamine release. Species:  Rat Tissue:  Cerebral cortex. References:  2
Inhibition of chemical and mechanical nociception. Species:  Rat Tissue:  In vivo. References:  10

Physiological Consequences of Altering Gene Expression
H3 receptor knockout mice exhibit hyperphagia and late-onset obesity. Species:  Mouse Tissue:  Technique:  Gene targeting in embryonic stem cells. References:  53
H3 receptor knockout mice exhibit normal circadian rhythmicity, but a decrease in locomotion, wheel-running behaviour and body temperature during the dark phase. Species:  Mouse Tissue:  Technique:  Gene targeting in embryonic stem cells. References:  54
H3 receptor knockout mice exhibit a mild obese phenotype, suggesting the H3 receptor may have a role in energy homeostasis. Species:  Mouse Tissue:  Technique:  Gene targeting in embryonic stem cells. References:  51
Sympathetic nerve endings from hearts from H3 receptor knockout mice exhibit an increase in basal noradrenaline release compared to hearts from wild-type mice. Species:  Mouse Tissue:  Technique:  Gene targeting in embryonic stem cells. References:  32
H3 receptor knockout mice exhibit increased spatial learning and memory as well as reduced levels of anxiety. Species:  Mouse Tissue:  Technique:  Gene targeting in embryonic stem cells. References:  48

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0001362 abnormal anxiety-related response PMID: 12130692  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl B6.129X1-Hrh3 MGI:2139279  MP:0005167 abnormal blood-brain barrier function PMID: 17548817  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0001777 abnormal body temperature regulation PMID: 12130692  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ MGI:2139279  MP:0001544 abnormal cardiovascular system physiology PMID: 12527809  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0005450 abnormal energy expenditure PMID: 12488429  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0003953 abnormal hormone level PMID: 15078574  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0003313 abnormal locomotor activation PMID: 12130692  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0003633 abnormal nervous system physiology PMID: 12130692  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0001463 abnormal spatial learning PMID: 15078574  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ MGI:2139279  MP:0005447 abnormal synaptic norepinephrine release PMID: 12527809  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0001364 decreased anxiety-related response PMID: 15078574  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0005534 decreased body temperature PMID: 12488429  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0005290 decreased oxygen consumption PMID: 12488429  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0001402 hypoactivity PMID: 12488429  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl involves: 129X1/SvJ * C57BL/6J MGI:2139279  MP:0001363 increased anxiety-related response PMID: 15078574  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0002079 increased circulating insulin level PMID: 12488429  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0005669 increased circulating leptin level PMID: 12488429  Hrh3tm1Twl Hrh3tm1Twl/Hrh3tm1Twl B6.129X1-Hrh3 MGI:2139279  MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis PMID: 17548817  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0005455 increased susceptibility to weight gain PMID: 12488429  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0010024 increased total body fat amount PMID: 12488429  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0005331 insulin resistance PMID: 12488429  Hrh3tm1Kot Hrh3tm1Kot/Hrh3tm1Kot involves: 129X1/SvJ * C57BL/6N MGI:2139279  MP:0001433 polyphagia PMID: 12488429

Biologically Significant Variants
Type:  Splice variants Species:  Human Description:  Expression of human H3 receptor splice variants in CHO cells show that a deletion in the 2nd transmembrane domain alters ligand binding and deletions in the 3rd intracellular loop result in signal transduction being abolished. References:  16
Type:  Splice variants Species:  Rat Description:  Various H3 receptor splice variants have been reported to exist rat tissues. When expressed in in CHO and COS-7 cells, some have altered pharmacological properties or cell surface trafficking. References:  4,41