lysine demethylase 2A | 1.14.11.- Histone demethylases | IUPHAR/BPS Guide to PHARMACOLOGY

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lysine demethylase 2A

Target not currently curated in GtoImmuPdb

Target id: 2671

Nomenclature: lysine demethylase 2A

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1162 11q13.1 KDM2A lysine demethylase 2A
Mouse - 1161 19 A Kdm2a lysine (K)-specific demethylase 2A
Rat - 1161 1q42 Kdm2a lysine demethylase 2A
Previous and Unofficial Names
FBXL11 | lysine (K)-specific demethylase 2A
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IOX2 Hs Inhibition 7.3 pIC50 1
pIC50 7.3 (IC50 5.2x10-8 M) [1]
daminozide Hs Inhibition 5.8 pIC50 2
pIC50 5.8 (IC50 1.5x10-6 M) [2]


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1. Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A et al.. (2013) Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem. Biol., 8 (7): 1488-96. [PMID:23683440]

2. Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J. Med. Chem., 55 (14): 6639-43. [PMID:22724510]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 2A. Last modified on 30/03/2016. Accessed on 18/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY,